Metabolisme in 'winterslaap' bij myalgische encefalomyelitis/chronische-vermoeidheidssyndroom
Een nieuw therapeutisch doelwit?

Myalgische encefalomyelitis/chronische-vermoeidheidssyndroom (ME/CVS), tegenwoordig ook wel systemic exercise intolerance disease (SEID), is een heterogene ziekte met een onbekende oorzaak. Het betreft een ernstige chronische ziekte, die het functioneren en de kwaliteit van leven aanzienlijk beperkt. De belangrijkste symptomen zijn vermoeidheid gedurende meer dan zes maanden, malaise na inspanning, slaapstoornissen, onvoldoende herstel na rust en slaap, cognitieve stoornissen, geheugen- en concentratieproblemen, spier- en gewrichtspijn, sensorische hypergevoeligheid en autonome disfunctie, waaronder orthostatische intolerantie. Er is geen overeenstemming of ME en CVS twee verschillende ziektes zijn en er is geen consensus over de diagnose en therapie. Diagnostiek conform de vijf criteria van het Amerikaanse Institute of Medicine (IOM) heeft momenteel de voorkeur.1 Cognitieve gedragstherapie (CBT) en graded exercise therapy (GET) behoren tot de therapeutische mogelijkheden,1 maar het succes daarvan is omstreden.2

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Auteur

Frits Muskiet

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