Ongeveer de helft van de premenopauzale vrouwen heeft gezondheidsklachten voorafgaande aan de menstruatie; drie tot negen procent van de vrouwen kampt met ernstige premenstruele klachten ofwel PMS (premenstrueel syndroom). PMDD (premenstrual dysphoric disorder) is een vorm van PMS waarbij ernstige psychische/psychosociale klachten op de voorgrond treden. Vooral vrouwen boven de dertig en vrouwen die kinderen hebben gekregen, krijgen last van PMS. De precieze oorzaak van PMS is onduidelijk. Ook zijn er relatief weinig wetenschappelijke studies gepubliceerd naar de werkzaamheid van voedingsstoffen en kruiden bij PMS/PMDD. Suppletie met calcium of monnikspeperbes en cognitieve gedragstherapie hebben vooralsnog de beste wetenschappelijke onderbouwing.1
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