Aan het belang van voedingsstoffen voor de behandeling van een hiv-infectie wordt in medische kring opvallend weinig betekenis gehecht. In vorig nummer (jg. 20 nr. 6) bleek dat te gelden voor vitaminen en mineralen, de in dit tweede deel te bespreken aminozuren vertonen eenzelfde beeld. De wetenschap leverde echter al sinds de komst van het virus aanwijzingen dat levensduur en levenskwaliteit gebaat zijn bij een optimale inname van aminozuren, via voedingseiwitten of supplementen. Vanwege beperkte data wordt hier voornamelijk ingegaan op het uit aminozuren gevormde glutathion en de alle aminozuren bevattende weiproteïne.
Beste bezoeker, u heeft geen toegang.
Enkel (web)abonnees hebben toegang tot tijdschriftartikelen. Het webabonnement is nog in de maak.
U kunt zich wel alvast (gratis) registreren en tal van andere webartikelen raadplegen!
Auteur
Verschenen in
Referenties
Eck HP, Gmünder H, Hartmann M, Petzoldt D, Daniel V, Dröge W. Low concentrations of acid-soluble thiol (cysteine) in the blood plasma of HIV-1-infected patients. Biol Chem Hoppe Seyler. 1989 Feb;370(2):101-8. https://www.ncbi.nlm.nih.gov/pubmed/2784973; Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, Cantin AM, Crystal RG. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet. 1989 Dec 2;2(8675):1294-8. https://www.ncbi.nlm.nih.gov/pubmed/2574255
Staal FJ, Roederer M, Israelski DM, Bubp J, Mole LA, McShane D, Deresinski SC, Ross W, Sussman H, Raju PA, et al. Intracellular glutathione levels in T cell subsets decrease in HIV-infected individuals. AIDS Res Hum Retroviruses. 1992 Feb;8(2):305-11. https://www.ncbi.nlm.nih.gov/pubmed/1540417; Helbling B, von Overbeck J, Lauterburg BH. Decreased release of glutathione into the systemic circulation of patients with HIV infection. Eur J Clin Invest. 1996 Jan;26(1):38-44. https://www.ncbi.nlm.nih.gov/pubmed/8682153
Stephensen CB, Marquis GS, Douglas SD, Kruzich LA, Wilson CM. Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults. Am J Clin Nutr. 2007 Jan;85(1):173-81. https://academic.oup.com/ajcn/article/85/1/173/4649263
Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, Deresinski SC, Herzenberg LA. Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1967-72. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20026
Sbrana E, Paladini A, Bramanti E, Spinetti MC, Raspi G. Quantitation of reduced glutathione and cysteine in human immunodeficiency virus-infected patients. Electrophoresis. 2004 Jun;25(10-11):1522-9. https://www.ncbi.nlm.nih.gov/pubmed/15188236
Nguyen D, Hsu JW, Jahoor F, Sekhar RV. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab. 2014 Jan;99(1):169-77. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879663
Borges-Santos MD, Moreto F, Pereira PC, Ming-Yu Y, Burini RC. Plasma glutathione of HIV-patients responded positively and differently to dietary supplementation with cysteine or glutamine. Nutrition. 2012 Jul;28(7-8):753-6. https://www.sciencedirect.com/science/article/pii/S0899900711003777?via%3Dihub
de Quay B, Malinverni R, Lauterburg BH. Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine. AIDS. 1992 Aug;6(8):815-9. https://www.ncbi.nlm.nih.gov/pubmed/1418777
De Rosa SC, Zaretsky MD, Dubs JG, Roederer M, Anderson M, Green A, Mitra D, Watanabe N, Nakamura H, Tjioe I, Deresinski SC, Moore WA, Ela SW, Parks D, Herzenberg LA, Herzenberg LA. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest. 2000 Oct;30(10):915-29. https://www.ncbi.nlm.nih.gov/pubmed/11029607
Spada C, Treitinger A, Reis M, Masokawa IY, Verdi JC, Luiz MC, Silveira MV, Michelon CM, Avila-Junior S, Gil lD, Ostrowskyl S. The effect of N-acetylcysteine supplementation upon viral load, CD4, CD8, total lymphocyte count and hematocrit in individuals undergoing antiretroviral treatment. Clin Chem Lab Med. 2002 May;40(5):452-5. https://www.ncbi.nlm.nih.gov/pubmed/12113286
Breitkreutz R, Pittack N, Nebe CT, Schuster D, Brust J, Beichert M, Hack V, Daniel V, Edler L, Dröge W. Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials. J Mol Med (Berl). 2000;78(1):55-62. https://www.ncbi.nlm.nih.gov/pubmed/10759030
Jariwalla RJ, Lalezari J, Cenko D, Mansour SE, Kumar A, Gangapurkar B, Nakamura D. Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection. J Altern Complement Med. 2008 Mar;14(2):139-46. http://www.ncbi.nlm.nih.gov/pubmed/18315507
Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV-seropositive individuals. Clin Invest Med. 1993 Jun;16(3):204-9. https://www.ncbi.nlm.nih.gov/pubmed/8365048
Micke P, Beeh KM, Schlaak JF, Buhl R. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Eur J Clin Invest. 2001 Feb;31(2):171-8. https://www.ncbi.nlm.nih.gov/pubmed/11168457
Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur J Nutr. 2002 Feb;41(1):12-8. https://www.ncbi.nlm.nih.gov/pubmed/11990003
Moreno YF, Sgarbieri VC, da Silva MN, Toro AA, Vilela MM. Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection. J Trop Pediatr. 2006 Feb;52(1):34-8. https://academic.oup.com/tropej/article/52/1/34/1643836
Wanke CA, Silva M, Knox TA, Forrester J, Speigelman D, Gorbach SL. Weight loss and wasting remain common complications in individuals infected with human immunodeficiency virus in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000 Sep;31(3):803-5. https://academic.oup.com/cid/article/31/3/803/299085; Mangili A, Murman DH, Zampini AM, Wanke CA. Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the nutrition for healthy living cohort. Clin Infect Dis. 2006 Mar 15;42(6):836-42. https://academic.oup.com/cid/article/42/6/836/286703
Erlandson KM, Li X, Abraham AG, Margolick JB, Lake JE, Palella Jr FJ, ... Brown TT (2016). Long-term impact of HIV wasting on physical function. AIDS, 30(3), 445-454. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712700
Olsen MF, Abdissa A, Kæstel P, Tesfaye M, Yilma D, Girma T, Wells JC, Ritz C, Mølgaard C, Michaelsen KF, Zerfu D, Brage S, Andersen AB, Friis H. Effects of nutritional supplementation for HIV patients starting antiretroviral treatment: randomised controlled trial in Ethiopia. BMJ. 2014 May 15;348:g3187. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022776
Sattler FR, Rajicic N, Mulligan K, Yarasheski KE, Koletar SL, Zolopa A, Alston Smith B, Zackin R, Bistrian B; ACTG 392 Study Team. Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial. Am J Clin Nutr. 2008 Nov;88(5):1313-21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797483
Dröge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 1997 Nov;11(13):1077-89. https://www.ncbi.nlm.nih.gov/pubmed/9367343
Shabert JK, Winslow C, Lacey JM, Wilmore DW. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition. 1999 Nov-Dec;15(11-12):860-4. https://www.ncbi.nlm.nih.gov/pubmed/10575661
New supplement treats AIDS wasting successfully. AIDS Alert. 1999 Apr;14(4):41-3. https://www.ncbi.nlm.nih.gov/pubmed/11366220
Dröge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 1997 Nov;11(13):1077-89. https://www.ncbi.nlm.nih.gov/pubmed/9367343
Clark RH, Feleke G, Din M, Yasmin T, Singh G, Khan FA, Rathmacher JA. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr. 2000 May-Jun;24(3):133-9. https://www.ncbi.nlm.nih.gov/pubmed/10850936
Rathmacher JA, Nissen S, Panton L, Clark RH, Eubanks May P, Barber AE, D'Olimpio J, Abumrad NN. Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters. JPEN J Parenter Enteral Nutr. 2004 Mar-Apr;28(2):65-75. https://www.ncbi.nlm.nih.gov/pubmed/15080599