Een (sterk) verhoogde doorlaatbaarheid van het darmepitheel door defecte tight junctions (lekkende darm) kan een belangrijke rol spelen bij het ontstaan en de progressie van een reeks aandoeningen, waaronder auto-immuunziekten, chronische ontstekingsziekten en allergieën. De kwaliteit van tight junctions kan verbeteren door het gebruik van verschillende voedingssupplementen en kruiden (waaronder probiotica, (langeketen) meervoudig onverzadigde vetzuren en quercetine).
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1. Suzuki T et al. Role of flavonoids in intestinal tight junction regulation. Journal of Nutritional Biochemistry 2011;22:401-408.
2. Arrieta MC et al. Alterations in intestinal permeability. Gut 2006;55:1512-1520.
3. Usami M et al. Effect of eicosapentaenoic acid (EPA) on tight junction permeability in intestinal monolayer cells. Clinical Nutrition 2001;20(4):351-359.
4. Fasano A et al. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Advanced Drug Delivery Reviews 2004;56:795-807.
5. Groot J et al. Stress-induced decrease of the intestinal barrier function. The role of muscarinic receptor activation. Ann N Y Acad Sci. 2000;915:237-46.
6. Ma TY et al. Ethanol modulation of intestinal epithelial tight junction barrier. Am J Physiol. 1999;276(4 Pt 1):G965-74.
7. Ferruzza S et al. Iron and copper alter tight junction permeability in human intestinal Caco-2 cells by distinct mechanisms. Toxicology in Vitro 2002;16:399-404.
8. Liu Z et al. Tight junctions, leaky intestines, and pediatric diseases. Acta Pædiatrica, 2005;94:386-393.
9. Li N et al. Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells. J Nutr. 2009;139:710-714.
10. Bischoff SC. ’Gut health’: a new objective in medicine? BMC Medicine 2011, 9:24.
11. Brun P et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G518-G525.
12. Ulluwishewa D et al. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141:769-776.
13. Miele L et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009;49(6):1877-87.
14. Watts T et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A 2005;102:2916-21.
15. Willemsen LE et al. Polyunsaturated fatty acids support epithelial barrier integrity and reduce IL-4 mediated permeability in vitro. Eur J Nutr. 2008;47(4):183-191.
16. Ohland CL et al. Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol 2010;298:G807-G819.
17. Förster C. Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol. 2008;130:55-70.
18. Amasheh M et al. Barrier effects of nutritional factors. Ann NY Acad Sci. 2009;1165:267-273.
19. Li Q et al. Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis. Febs J. 2008;275:411-420.
20. Li Q et al. n-3 Polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines. Mol Immunol 2008;45:1356-1365.
21. Zhong W et al. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol Gastrointest Liver Physiol 2010;298:G625–G633.
22. Suzuki T et al. Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells. J Nutr. 2011;141(1):87-94.
23. Marchbank T et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol. 2011;300:G477-G484.
24. Fasano A et al. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Adv Drug Deliv Rev. 2004;56(6):795-807.
25. Sturniolo GC et al. The many functions of zinc in inflammatory conditions of the gastrointestinal tract. J Trace Elem Exp Med. 2000;13:33-9.
