Mestcellen, voor het eerst beschreven door Paul Ehrlich in 1876, zijn vooral berucht vanwege hun rol bij IgE-gemedieerde (type 1, directe type) allergieën. Mede door gebruik te maken van (genetisch) mestcel-deficiënte proefdieren zijn wetenschappers de laatste jaren veel te weten gekomen over de invloed van mestcellen op gezondheid en ziekte.1,2 Niet alleen blijken mestcellen een prominente rol te spelen bij allergieën, maar ook bij onder meer atherosclerose, trombose, aorta aneurysma, ischemie-reperfusieschade, onvruchtbaarheid bij mannen, auto-immuunziekten (waaronder reumatoïde artritis en multiple sclerose), PDS (prikkelbaredarmsyndroom), blaaspijnsyndroom (interstitiële cystitis), ALS (amyotrofische lateraalsclerose), obesitas en diabetes mellitus.1-3 Bij deze aandoeningen is het stabiliseren van mestcellen en/of het remmen van de activiteit van mestcelmediatoren zoals histamine een nieuw aangrijpingspunt voor therapie. Natuurlijke mestcel stabilisatoren zijn onder meer curcumine, L-theanine, bioflavonoïden (waaronder quercetine, luteoline, apigenine), palmitoylethanolamide, pycnogenol, omega-3-vetzuren en diverse kruiden.
Beste bezoeker, u heeft geen toegang.
Enkel (web)abonnees hebben toegang tot tijdschriftartikelen. Het webabonnement is nog in de maak.
U kunt zich wel alvast (gratis) registreren en tal van andere webartikelen raadplegen!
Auteur
Figuren
Verschenen in
Referenties
Anand P et al. Mast cells: an expanding pathophysiological role from allergy to other disorders. Naunyn-Schmiedeberg's Arch Pharmacol. 2012;385:657-670.
da Silva EZ et al. Mast cell function: a new vision of an old cell. J Histochem Cytochem. 2014;62(10):698-738.
Nirmal SA et al. Mast cell degranulation: a target for bioactive natural products. Phytopharmacol. 2013;4(3):575-597.
Wernersson S et al. Mast cell secretory granules: armed for battle. Nat Rev Immunol. 2014;14(7):478-94.
Finn DF et al. Twenty-first century mast cell stabilizers. Br J Pharmacol. 2013;170(1):23-37.
Krystel-Whittemore M et al. Mast cell: a multi-functional master cell. Front Immunol. 2016;6:620.
Bot I et al. Mast cells as effectors in atherosclerosis . Arterioscler Thromb Vasc Biol. 2015;35(2):265–71.
Azadi L et al. Zaditen (Ketotifen), as mast cell blocker, improves sperm quality, chromatin integrity and pregnancy rate after varicocelectomy. Int J Androl. 2011;34:446-452.
Walker ME et al. New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action? Biochim Biophys Acta. 2012;1822:57-65.
Theoharides TC. Luteolin as a therapeutic option for multiple sclerosis. J Neuroinflammation. 2009;6:29.
Theoharides TC et al. Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. Adv Exp Med Biol. 2007;601:423-30.
Lock C et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002;8:500-508.
Rudick CN et al. Mast cell-derived histamine mediates cystitis pain. PLoS One. 2008;3:e2096.
Walker MM et al. The role of eosinophils and mast cells in intestinal functional disease. Curr Gastroenterol Rep. 2011;13:323-330.
Klooker TK et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010;59:1213-1221.
Trias E et al. Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS. JCI Insight. 2017;2(20).
Piette F et al. Masitinib as an adjunct therapy for mild-tomoderate Alzheimer’s disease: a randomised, placebo-controlled phase 2 trial. Alzheimers Res Ther. 2011;3:16.
Keppel Hesselink JM. New targets in pain, non-neuronal cells, and the role of palmitoylethanolamide. Open Pain J. 2012;5:12-23.
Liu J et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009;15:940-945.
Wang J et al. Mast cell stabilization: novel medication for obesity and diabetes. Diabetes Metab Res Rev. 2011;27:919-924.
Zheng JM et al. Pathogenic role of mast cells in the development of diabetic nephropathy: a study of patients at different stages of the disease. Diabetologia. 2012;55:801-811.
Choi YH et al. Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction. Anat Cell Biol. 2010;43(4):317-24.
Cho YS et al. alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Allergy Clin Immunol. 2004;114:429-435.
Lee JH et al. Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol. 2008;121(5):1225-31.
Choi YH et al. Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation. Anat Cell Biol. 2010;43(1):36-43.
Li GZ et al. Inhibitory effects of epigallocatechin gallate on compound 48/80-induced mast cell activation and passive cutaneous anaphylaxis. Exp Mol Med. 2005;37(4):290-6.
Kim NH et al. Theanine is a candidate amino acid for pharmacological stabilization of mast cells. Amino Acids. 2012;42:1609-1618.
Chandrashekhar VM et al. Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model. J Ethnopharmacol. 2011;137(1):336-340.
Kritas SK et al. Luteolin inhibits mast cell-mediated allergic inflammation. J Biol Regul Homeost Agents. 2013;27(4):955-9.
Shaik YB et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006c;20(3-4):47-52.
Hattori M et al. Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells. Int Immunopharmacol. 2013;15(2):232-9.
Weng Z et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805.
Liu ZQ et al. Vitamin D contributes to mast cell stabilization. Allergy. 2017;72(8):1184-1192.
Yip KH et al. Mechanisms of vitamin D(3) metabolite repression of IgE-dependent mast cell activation. J Allergy Clin Immunol. 2014;133(5):1356-1364, 1364.e1351-1314.
Takemoto S et al. Magnesium deficiency induces the emergence of mast cells in the liver of rats. J Nutr Sci Vitaminol (Tokyo). 2013;59(6):560-3.
Ishiguro S et al. Effects of magnesium deficiency on dermal mast cells in rats. Nihon Yakurigaku Zasshi. 1987;89(3):121-7.
Weglicki WB et al. Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis. Am J Physiol. 1992;263(3 Pt 2):R734-7.
Lee SH et al. Serum micronutrients levels and clinical features of elderly asthmatics. Allergy Asthma Respir Dis. 2017;5:223-227.
Ciarallo L et al. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med. 2000;154(10):979-83.
Ohbori K et al. Prophylactic oral administration of magnesium ameliorates dextran sulfate sodium-induced colitis in mice through a decrease of colonic accumulation of P2X7 receptor-expressing mast cells. Biol Pharm Bull. 2017;40:1071-1077.
Domínguez CM et al. N-palmitoylethanolamide in the treatment of neuropathic pain associated with lumbosciatica. Pain Manag. 2012;2(2):119-24.
De Filippis D et al. New insights in mast cell modulation by palmitoylethanolamide. CNS Neurol Disord Drug Targets. 2013;12(1):78-83.
Roviezzo F et al. Palmitoylethanolamide supplementation during sensitization prevents airway allergic symptoms in the mouse. Front Pharmacol. 2017;8:857.
Wang X et al. n-3 Polyunsaturated fatty acids inhibit Fc ε receptor I-mediated mast cell activation. J Nutr Biochem. 2015;26(12):1580-8.
Choi YH et al. Pycnogenol inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res. 2009;23(12):1691-5.
Sharma SC et al. Pycnogenol inhibits the release of histamine from mast cells. Phythother Res. 2003;17:66-69.
Maimoona A et al. A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract. J Ethnopharmacol. 2011;133:261-277.
Hosseini S et al. Pycnogenol in the management of asthma. J Med Food 2001;4:201-9.
Wilson D et al. A randomized, double-blind, placebocontrolled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 2010;24(8):1115-9.
Theoharides TC, Bielory L. Mast cells and mast cell mediators as targets of dietary supplements. Ann Allergy Asthma Immunol. 2004;93(2 Suppl 1):S24-34.
Yang HN et al. Spirulina platensis inhibits anaphylactic reaction. Life Sci. 1997;61(13):1237-44.
Aswar U et al. Antiallergic effect of piperine on ovalbumin-induced allergic rhinitis in mice. Pharm Biol. 2015;53(9):1358-1366.
Kandhare AD et al. Ameliorative effects of type-A procyanidins polyphenols from cinnamon bark in compound 48/80-induced mast cell degranulation. Anat Cell Biol. 2017;50:275-283.
Chen BH et al. Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). J Nat Prod. 2009;72:950-953.
Kim HH et al. Galangin attenuates mast cell-mediated allergic inflammation. Food Chem Toxicol. 2013;57:209-16.
Jeong HJ et al. Inhibitory effects of mast cell-mediated allergic reactions by cell cultured Siberian Ginseng. Immunopharmacol Immunotoxicol. 2001;23(1):107-17.
George M et al. Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts. Afr J Tradit Complement Altern Med. 2009;6(4):554-9.
Roschek Jr B et al. Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytother Res. 2009;23:920-926.
Kim DS et al. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Planta Med. 2010;76(7):678-82.
Jung HS et al. Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro. J Ethnopharmacol. 2012;141(1):345-9.
Chung JH et al. Inhibitory effects of Syzygium aromaticum ethanol extracts on IgE mediated RBL-2H3 cell activation. Korean J Acupunct. 2014;31:14-19.
De Filippis D et al. Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Mol Pain. 2011; 7:3.
