Ashwagandha (Withania somnifera of winterkers, een plant uit de solanaceae familie) is een belangrijk fytotherapeuticum uit India, Zuid-Azië, Centraal-Azië en delen van Afrika. De Sanskriet benaming ashwa (paard) gandha (geur) verwijst naar de typische geur van de verse wortel.
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Referenties
1. Singh N et al. An overview of ashwagandha: a rasayana (rejuvenator) of ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5S):208-213.
2. Durg S et al. Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis. J Pharm Pharmacol. 2015;67(7):879-99.
3. Chandrasekhar K et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-62.
4. Alam N et al. Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits. Phytochem Rev. 2012;11(1):1-16.
5. Mishra LC et al. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000;5(4):334-46.
6. Wankhede S et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43.
7. Nemeroff CB. Psychoneuroimmunoendocrinology: the biological basis of mind-body physiology and pathophysiology. Depress Anxiety. 2013;30(4):285-7.
8. Mirjalili MH et al. Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules 2009;14:2373–93.
9. Widodo N et al. Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves. J Gerontol A Biol Sci Med Sci. 2009;64(10):1031-8.
10. Chang BD et al. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A. 2000;97(8):4291-6.
11. Kushwaha S et al. Effect of Ashwagandha (Withania somnifera) root powder supplementation in treatment of hypertension. Ethno Med. 2012;6(2):111-115.
12. Pratte MA et al. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014;20(12):901-8.
13. Auddy B et al. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study. JANA 2008;11(1):50-56.
14. Bhatnagar M et al. Neuroprotective effects of Withania somnifera dunal.: A possible mechanism. Neurochem Res. 2009;34(11):1975-83.
15. Andrade C et al. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera. Indian J Psychiatry. 2000;42(3):295-301.
16. Bhattacharya SK, et al. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000;7(6):463-9.
17. Candelario M et al. Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors. J Ethnopharmacol. 2015;171:264-72.
18. Kaurav BP et al. Influence of Withania somnifera on obsessive compulsive disorder in mice. Asian Pac J Trop Med. 2012;5(5):380-4.
19. Shah PC et al. Effect of Withania somnifera on forced swimming test induced immobility in mice and its interaction with various drugs. Indian J Physiol Pharmacol. 2006;50(4):409-15.
20. Tripathi AK et al. Alterations in the sensitivity of 5(th) receptor subtypes following chronic asvagandha treatment in rats. Anc Sci Life. 1998;17(3):169-81.
21. Kumar A et al. Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism. Indian J Pharm Sci. 2008;70(6):806-10.
22. Kumar A et al. Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method). Indian J Exp Biol. 2007;45(6):524-8.
23. Orrù A et al. Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine. Phytomedicine. 2014;21(5):745-52.
24. Raut AA et al. Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. J Ayurveda Integr Med. 2012;3(3):111-4.
25. Pingali U et al. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy Res. 2014;6(1):12-18.
26. Chengappa KN et al. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013;74(11):1076-83.
27. Schliebs R et al. Systemic administration of defined extracts from Withania somnifera (Indian ginseng) and shilajit differentially affects cholinergic but not glutamatergic and gabaergic markers in rat brain. Neurochem Int. 1997;30:181-190.
28. Choudhary MI et al. Cholinesterase inhibiting wi¬thanolides from Withania somnifera. Chem Pharm Bull (Tokyo). 2004;52(11):1358-61.
29. Kataria H et al. Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PLoS One. 2012;7(5):e37080.
30. Soman S et al. Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A. Neurochem Res. 2012;37(9):1915-27.
31. Baitharu I et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One. 2014;9(10):e105311.
32. Kuboyama T et al. Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha. Neuroreport. 2002;13(14):1715-20.
33. Kuboyama T et al. Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases. Biol Pharm Bull. 2014;37(6):892-7.
34. Kuboyama T et al. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol. 2005;144(7):961-71.
35. Kurapati KR et al. β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A. PLoS One. 2014;9(11):e112818.
36. Prakash J et al. Withania somnifera alleviates parkinsonian phenotypes by inhibiting apoptotic pathways in dopaminergic neurons. Neurochem Res. 2014;39(12):2527-36.
37. RajaSankar S et al. Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson’s disease model mouse. J Ethnopharmacol. 2009;125(3):369-73.
38. Rao RV et al. Ayurvedic medicinal plants for Alzheimer’s disease: a review. Alzheimer’s Research & Therapy 2012;4:22.
39. Raghavan A et al. Withania somnifera improves ischemic stroke outcomes by attenuating PARP1-AIF-mediated caspase-independent apoptosis. Mol Neurobiol. 2015;52(3):1093-105.
40. Dries DR et al. Extracting β-amyloid from Alzheimer’s disease. Proc Natl Acad Sci U S A. 2012;109(9):3199-200.
41. Winters M. Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev. 2006;11(4):269-277.
42. Rasool M et al. Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study. Vascul Pharmacol. 2006;44(6):406-10.
43. Chaudhari D et al. Phytochemical analysis and evaluation of antioxidant and free radical scavenging activity of Withania somnifera root. Asian J Pharm Clin Res. 2012;5:193-199.
44. Orrù A, et al. Withania somnifera (L.) Dunal root extract alleviates formalin-induced nociception in mice: involvement of the opioidergic system. Behav Pharmacol. 2016;27(1):57-68.
45. Alam N et al. Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities. BMC Complemen Altern Med. 2012;12:175.
46. Singh G et al. Evaluation of antimicrobial efficacy of flavonoids of Withania somnifera L. Indian J Pharm Sci. 2011;73(4):473-478.
47. Datta S et al. Inhibition of the emergence of multi drug resistant Staphylococcus aureus by Wi¬thania somnifera root extracts. Asian Pac J Trop Med. 2011;4(11):917-20.
48. Owais M et al. Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis. Phytomedicine. 2005;12:229-235.
49. Rai M et al. Anticancer activities of Withania somnifera: Current research, formulations, and future perspectives. Pharm Biol. 2016;54(2):189-97.
50. Singh N et al. Role of Withania somnifera in prevention and treatment of cancer: an overview. Int J Pharmac Sci Drug Res. 2011;3(4):274-279.
51. Biswal BM et al. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
52. Kataria H et al. Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas. PLoS One. 2013;8(1):e55316.
53. Kataria H et al. Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells. Mol Neurobiol. 2015 Jul 26.
54. Wadegaonkar VP et al. Withanone as an inhibitor of survivin: a potential drug candidate for cancer therapy. J Biotechnol. 2013;168(2):229-33.
55. Grover A et al. Withanone binds
to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence. Int J Biochem Cell Biol. 2012;44(3):496-504.
56. Kataria H et al. Withania somnifera aqueous extract facilitates the expression and release of GnRH: In vitro and in vivo study. Neurochem Int. 2015;89:111-9.
57. Ahmad MK et al. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertil Steril. 2010;94(3):989-96.
58. Shukla KK et al. Withania somnifera improves semen quality by combating oxidative stress and cell death and improving essential metal concentrations. Reprod Biomed Online. 2011;22(5):421-7.
59. Mamidi P et al. Efficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunction. Ayu. 2011;32(3):322-328.
60. Dongre S et al. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Biomed Res Int. 2015;2015:284154.
61. Ambiye VR et al. Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study. Evid Based Complement Alternat Med. 2013;2013:571420.
62. Mahdi AA et al. Withania somnifera improves semen quality in stress-related male fertility. Evid Based Complement Alternat Med. 2011;2011:576962.
63. Kyathanahalli CN et al. Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats. Protoplasma 2014;251(5):1021-9.
64. Panda S et al. Changes in thyroid hormone concentration after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol. 1998;50(9):1065-8.
65. Panda S et al. Combined effects of ashwagandha, guggulu and bauhinia extracts in the regulation of thyroid function and on lipid peroxidation in mice. J Pharm Pharmacol. 2000;6(3):141-143.
66. Gannon JM et al. Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder. J Ayurveda Integr Med. 2014;5(4):241-5.
67. Anwer T et al. Effect of Withania somnifera on insulin sensitivity in non-insulin-dependent diabetes mellitus rats. Basic Clin Pharmacol Toxicol. 2008;102:498-503.
68. Udayakumar R et al. Antioxidant effect of dietary supplement Withania somnifera L. reduces blood glucose levels in alloxan-induced diabetic rats. Plant Foods Hum Nutr. 2010;65:91-98.
69. Jaiswal D et al. Antidiabetic effect of Withania coagulans in experimental rats. Indian J Clin Biochem. 2009;24:88-93.
70. Bhattacharya SK et al. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003;75(3):547-55. 71. Andallu B et al. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol. 2000;38(6):607-9.
72. Agnihotri AP et al. Effects of Withania somnifera in patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013; 45(4): 417–418.
73. Khalili M. The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats. Basic Clin Neurosci. 2009;1(1):29-31.
74. Malik A et al. Effect of ashwagandha (Withania somnifera) root powder supplementation on the VO2max and hemoglobin in hockey players. Int J Behavioral Social and Movement Sciences 2013;2(3):91-99.
75. Shenoy S et al. Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists. J Ayurveda Integr Med. 2012;3(4):209-214.
76. Sandhu JS et al. Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. Int J Ayurveda Res. 2010;1(3):144-9.
77. Raut A et al. Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. J Ayurveda Integrative Med. 2012:111.
78. Sumantran VN et al. Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis. J Biosci. 2007;32(2):299-307.
79. Sumantran VN et al. The relationship between chondroprotective and antiinflammatory effects of Withania somnifera root and glucosamine sulphate on human osteoarthritic cartilage in vitro. Phytother Res. 2008;22(10):1342-8.
80. Rasool M et al. Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study. Chem Biol Interact. 2006;164(3):174-80.
81. Gupta A et al. Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats. Pharm Biol. 2014;52(3):308-20.
82. Mohanty I et al. Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic Clin Pharmacol Toxicol. 2004;94(4):184-90.
83. Mohanty IR et al. Withania somnifera provides cardioprotection and attenuates ischemia-reperfusion induced apoptosis. Clin Nutr. 2008;27(4):635-42.
84. Mehra R et al. An approach of ashwagandha + guggulu in atheromatous CHD associated with obesity. J Res Ayu 2009;30(2):121-125.
85. Gupta SK et al. Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment. Mol Cell Biochem. 2004;260(1-2):39-47.
86. Chaudhary G et al. Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats. Clin Exp Pharmacol Physiol. 2003;30(5-6):399-404.
87. Raghavan A et al. Withania somnifera: a pre-clinical study on neuroregenerative therapy for stroke. Neural Regen Res. 2015;10(2):183-5. 88. Van der Hooft CS et al. Thyrotoxicosis following the use of Ashwagandha. Ned Tijdschr Geneeskd 2005;149:2637-8.
89. Davis L et al. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-214.
90. Gupta YK et al. Reversal of paclitaxel induced neutropenia by Withania somnifera in mice. Indian J Physiol Pharmacol. 2001;45(2):253-7.
91. Senthilnathan P et al. Chemotherapeutic efficacy of paclitaxel in combination with Withania somnifera on benzo(a)pyrene-induced experimental lung cancer. Cancer Sci. 2006;97(7):658-64.
92. Sultana N et al. Effects of ashwagandha (Withania somnifera) root extract on some serm liver marker enzymes (AST, ALT) in gentamicin intoxicated rats. J Bangladesh Soc Physiol. 2012;7(1):1-7.
93. Shimmi SC et al. Effect of ashwagandha (Withania somnifera) root extract against gentamicin induced changes of serum urea and creatinine levels in rats. J Bangladesh Soc Physiol. 2011;6(2):84-89.
94. Nair V et al. Effect of Withania somnifera root extract on haloperidol-induced catalepsy in albino mice. Phytother Res. 2008;22(2):243-6.
95. Naidu PS et al. Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action. J Med Food. 2003;6(2):107-14.
96. Al-Awthan YS et al. Effects of aqueous extract of Withania somnifera on some liver biochemical and histopathological parameters in male guinea pigs. Pak J Biol Sci. 2014;17(4):504-10.
97. Kumar P et al. Glioprotective effects of Ashwagandha leaf extract against lead induced toxicity. Biomed Res Int. 2014;2014:182029.
98. Bharavi K et al. Prevention of cadmium bioaccumulation by herbal adaptogens. Indian J Pharmacol. 2011;43(1):45-9.
99. Gupta GL et al. Effect of Withania somnifera Dunal in ethanol-induced anxiolysis and withdrawal anxiety in rats. Indian J Exp Biol. 2008;46(6):470-5.
100. Andallu B et al. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
101. Bhattacharya A et al. Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol. 2001;74(1):1-6.
102. Chaurasia SS, Panda S, Kar A. Withania somnifera root extract in the regulation of lead-induced oxidative damage in male mouse. Pharmacol Res. 2000;41(6):663-6.
103. Khan MA et al. Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats. J Complement Integr Med. 2015;12(2):117-25