Insulineresistentie en overgewicht zijn twee factoren die de laatste dertig jaar sterk zijn toegenomen. Oorzaken zijn gelegen in vooral verandering van gedrag, voeding en beweging. Simpel gezegd ontstaat overgewicht door de inname van een grotere hoeveelheid caloriën dan verbruikt wordt, oftewel de oudste wet van thermodynamica (zie afbeelding 1) 1,2.
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