Niet cholesterol maar homocysteïne is aartsvijand van het hart?
Toxicologie van homocysteïne

De medische wereld beschouwt cholesterol nog steeds als de grote boosdoener van het hart, ondanks de vele tegenstrijdige resultaten. Homocysteïne staat veel sterker. Cholesterol zelf is niet toxisch, integendeel is het een levensnoodzakelijke stof. Homocysteïne heeft geen essentiële functie, buiten dat het geproduceerd moet worden. Een noodzakelijk kwaad.

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Auteur

Joost Meeusen

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  1. Ahn CS. Effect of taurine supplementation on plasma homocysteine levels of the middle-aged Korean women. Adv Exp Med Biol, 2009; 643:415-22

  2. Almeida OP et al. B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial. Ann Neurol. 2010 Oct;68(4):503-10

  3. Armitage JM, Bowman L et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010 Jun 23;303(24):2486-94

  4. Atkinson w, Slow S et al. Dietary and supplementary betaine: Effects on betaine and homocysteine concentrations in males. Nutrition, Metabolism & Cardiovascular Diseases (2009) 19:767-773

  5. Baggott JE, Tamura T. Iron-dependent formation of homocysteine from methionine and other thioethers. Eur J Clin Nutr. 2007 Dec;61(12):1359-63. Epub 2007 Feb 14

  6. Bethin KE, Cimato TR et al. Copper binding to mouse liver S-adenosylhomocysteine hydrolase and the effects of copper on its levels. J Biol Chem. 1995 Sep 1;270(35):20703-11.

  7. Bethin KE, Petrovic N et al. Identification of a major hepatic copper binding protein as S-adenosylhomocysteine hydrolase. J Biol Chem. 1995 Sep 1;270(35):20698-702

  8. Boldyrev AA. Molecular mechanisms of homocysteine toxicity. Biochemistry (Moscow); 2009; 74(6):589-598

  9. Breilmann J, Pons-Kühnemann J et al. Effect of Antioxidant Vitamins on the Plasma Homocysteine Level in a Free-Living Elderly Population. Ann Nutr Metab. 2010 Nov 17;57(3-4):177-182. [Epub ahead of print]

  10. Chai H, Dong Y et al. Ginsenoside Rb1 attenuates homocysteine-augmented guidewire injury-induced intimal hyperplasia in mice. J Surg Res. 2009 Dec;157(2):193-8. Epub 2008 Aug 15

  11. Chang P-Y, Lu S-C et al. S-Adenosylhomocysteine: A Better Marker of the Development of Alzheimer's Disease than Homocysteine? Journal of Alzheimer's Disease. 10.3233/JAD-2010-100144

  12. Clarke R, Halsey J, Lewington S et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010 Oct 11;170(18):1622-31.

  13. Craig SAS. Betaine in human nutrition. Am J Clin Nutr. 2004; 80:539-49

  14. Glomerular Injury and Sclerosis. Am J Nephrol 2008;28:254–264

  15. Green TJ, Skeaff CM et al. Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations. Br J Nutr. 2010 Jun;103(11):1629-34. Epub 2010 Jan 21.

  16. Hodis HN, Mack WJ et al. High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke. 2009 Mar;40(3):730-6. Epub 2008 Dec 31.

  17. Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005 Oct;82(4):806-12

  18. Hung C-J, Huang P-C, Lu S-C, et al. Plasma Homocysteine Levels in Taiwanese Vegetarians Are Higher Than Those of Omnivores. J Nutr, 2002;132:152-158

  19. Jakubowski H. Molecular basis of homocysteine toxicity in humans. Cell Mol Life Sci. 2004; 61:470-487

  20. Jakubowski H. The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. J Physiol Pharmacol. 2008 Dec;59 Suppl 9:155-67. Review.

  21. Jakubowski J. The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. Journal of physiology and pharmacology. 2008, 59, suppl 9, 155-167

  22. Kim JH et al. Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res. 2007 Mar 9;1136(1):190-9. Epub 2006 Dec 22.

  23. Kim JH, Cho SY et al. Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia. Biol Pharm Bull. 2006 Dec;29(12):2425-31

  24. Koubaa N, Nakbi A et al. Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome. Clin Biochem. 2009 Jun;42(9):771-6. E-pub 2009 Mar 6

  25. McCully KS. The biomedical significance of homocysteine. Journal of Scientific Exploration; 2001; 15(1):5–20

  26. Mouhamed DH, Ezzaher A et al. Effect of cigarette smoking on plasma homocysteine concentrations. Clin Chem Lab Med. 2010 Dec 14. [Epub ahead of print]

  27. Nafar M, Khatami F et al. Role of folic acid in atherosclerosis after kidney transplant: a double-blind, randomized, placebo-controlled clinical trial. Exp Clin Transplant. 2009 Mar;7(1):33-9

  28. Ntaios G, Savopoulos C et al. The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial. Int J Cardiol. 2010 Aug 6;143(1):16-9. Epub 2009 Feb 8.

  29. Nys Marleen. Paraoxonasen, beschermers tegen degeneratieziekten en toxiciteit. Arts & Apotheker. 2010; 11(2): 42-47

  30. Obeid R, Herrmann W. Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects. Clin Chem Lab Med. 2005;43(10):1052-7

  31. Papandreou D, Rousso I et al. Effects of oral folate supplementation on serum total homocysteine and cholesterol levels in hyperhomocysteinemic children. Nutr Clin Pract. 2010 Aug;25(4):390-3

  32. Perla-Kaján J, Jakubowski H. Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB J. 2010 Mar;24(3):931-6. Epub 2009 Oct 30.

  33. Pooya S, Jalali MD et al. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr Metab Cardiovasc Dis, 2009 June 18

  34. Ramakrishnan S, Sulochana KN et al. Biochemistry of homocysteine in health and diseases. Indian Journal of Biochemistry & Biophysics. 2006; 43:275-283

  35. Ravaglia G, Forti P et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr. 2005; 82:636-43

  36. Stabler SP, Allen RH et al. Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment. Am J Clin Nutr. 2006 Dec;84(6):1422-9

  37. Stanger O, Fowler B et al. Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations. Expert Rev. Neurother. 9(9), 1393–1412 (2009)

  38. Stehouwer CDA, van Gulder Coen. Does homocysteïne cause hypertension? Clin Chem Lab Med 2003; 41(11):1408–1411

  39. Stover PJ. Vitamin B12 and older adults. Curr Opin Clin Nutr Metab Care. 2010; 13:24-27

  40. Van Guelpen B, Hultdin J et al. Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function. J Intern Med. 2009 Aug;266(2):182-95. Epub 2009 Feb 27.

  41. van Guldener Coen. Homocysteine and the kidney. Curr Drugs Metab. 2005; 6:23-26

  42. Verhoef P, de Groot LC. Dietary determinants of plasma homocysteine concentrations. Semin Vasc Med. 2005 May;5(2):110-23.

  43. Wagner C, Koury MJ. S-Adenosylhomocysteine—a better indicator of vascular disease than homocysteine? Am J Clin Nutr 2007;86:1581–5.

  44. Weiss N, Ide N et al. Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro- and microcirculation. J Nutr. 2006 Mar;136(3 Suppl):750S-754S

  45. Yeh YY, Yeh SM. Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract. J Nutr. 2006 Mar;136(3 Suppl):745S-749S.

  46. Yi F, Li P-L. Mechanisms of Homocysteine-Induced

  47. Yilmaz H, Sahin S et al. Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease. Acta Cardiol, 2007; 62(6):579-85

  48. Zhou Ji, Austin RC. Contributions of hyperhomocysteinemia to atherosclerosis: causal relationship and potential mechanisms. Cofactors. 2009; 35(2):120-129

  49. Zoccolella S, dell'Aquila C et al. Elevated homocysteine levels in Parkinson's Disease: is there anything besides L-dopa treatment? Curr Med Chem. 2010;17(3):213-21

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