Alles over B12
B12 Schema

Beschrijving

Vitamine B12 is, zoals de naam al zegt, onderdeel van de vitamine B familie, het vitamine B-Complex. De andere naam voor vitamine B12 is cobalamine of extrinsieke factor. Cobalamines zijn in water oplosbare verbindingen met vitamine B12 activiteit. Ze worden gekenmerkt door een grote en complexe chemische structuur die een kobalt ion bevat. Het zijn de enige bekende natuurlijk voorkomende kobalthoudende verbindingen in de natuur. Cobalamine werd in 1926 ontdekt en het werd geïsoleerd uit lever. Bij mensen fungeren cobalamines als cofactor voor twee enzymen, te weten methioninesynthase en methylmalonyl co-enzym A mutase, wat belangrijke enzymen zijn in respectievelijk de DNA-stofwisseling en de productie van energie uit eiwitten en vetten.

Voor dat vitamine B12 bekend was werd bij ziekten die het gevolg waren van B12-gebrek leverextract gebruikt, zonder dat men wist waarom dit hielp. Leverextract als bron van B12 is inmiddels verleden tijd; de vitamine wordt nu gemaakt met behulp van speciaal voor dit doel geselecteerde bacteriën.

Beste bezoeker

Gelieve u aan te melden om dit artikel te lezen. Registreer u hier, snel en gratis!

Product op maat

B12 Combi 6000 met folaat

Trefwoorden

Referenties

  1. Vitamin B12 (cobalamin) deficiency in elderly patients Emmanuel Andrès, Noureddine H. Loukili, Esther Noel, Georges Kaltenbach, Maher Ben Abdelgheni, Anne E. Perrin, Marie Noblet-Dick, Frédéric Maloisel, Jean-Louis Schlienger, Jean-Frédéric Blicklé CMAJ2004;171(3):251-9
  2. Cobalamin: a critical vitamin in the elderly Preventive Medicine 39 (2004) 1256- 1266
  3. Clarke R, Grimley Evans J, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;33:34-41.
  4. Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study Henning Tiemeier, M.D., H. Ruud van Tuijl, M.Sc., Albert Hofman, M.D., Ph.D., John Meijer, M.Sc., Amanda J. Kiliaan, Ph.D. and Monique M.B. Breteler, M.D., Ph.D.Am J Psychiatry 159:2099-2101, December 2002
  5. Absence of macrocytic anaemia in Alzheimer’s disease Clin. Lab. Haem. 2004, 26, 259-263 (5)
  6. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Morris MC, Evans DA, Bienias JL, et al. Arch Neurol 2005;62:641-5.
  7. Clinical relevance of lowserum vitamin B12 concentrations in older people: Banbury B12 Study. Hin H, Clarke R, Sherliker P, et al. Age Ageing 2006;35:416-22.
  8. Department of Health. Folate and disease prevention. London: Scientific Advisory Committee on Nutrition, 2006. 2006 Massachusetts Medicaly Society.
  9. Functional vitamin B12 deficiency and Alzheimer disease McCaddon, MRCGP; B. Regland, MD, PhD; P. Hudson, MSc; and G. Davies, MSc NEUROLOGY 2002;58:1395-1399
  10. Clinical significance of low cobalamin levels in older hospital patients Dieneke Z. van Asselt , Henk J. Blom , Richard Zuiderent , Ron A. Wevers , Cornelis Jakobs , Wim J. van den Broek , Cornelis B. Lamers , Frans H. Corstens , Willibrord H. Hoefnagels*. The Netherlands Journal of Medicine 2000;57:41-49
  11. Vitamin B12 (cobalamin) deficiency in elderly patients Emmanuel Andrès, Noureddine H. Loukili, Esther Noel, Georges Kaltenbach, Maher Ben Abdelgheni, Anne E. Perrin, Marie Noblet-Dick, Frédéric Maloisel, Jean-Louis Schlienger, Jean-Frédéric Blicklé CMAJ2004;171(3):251-9
  12. Cobalamin: a critical vitamin in the elderly Preventive Medicine 39 (2004) 1256- 1266
  13. Clarke R, Grimley Evans J, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;33:34-41.
  14. Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study Henning Tiemeier, M.D., H. Ruud van Tuijl, M.Sc., Albert Hofman, M.D., Ph.D., John Meijer, M.Sc., Amanda J. Kiliaan, Ph.D. and Monique M.B. Breteler, M.D., Ph.D.Am J Psychiatry 159:2099-2101, December 2002
  15. Absence of macrocytic anaemia in Alzheimer’s disease Clin. Lab. Haem. 2004, 26, 259-263 (5) McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  16. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Morris MC, Evans DA, Bienias JL, et al. Arch Neurol 2005;62:641-5.
  17. Clinical relevance of lowserum vitamin B12 concentrations in older people: Banbury B12 Study. Hin H, Clarke R, Sherliker P, et al. Age Ageing 2006;35:416-22.
  18. Department of Health. Folate and disease prevention. London: Scientific Advisory Committee on Nutrition, 2006. 2006 Massachusetts Medicaly Society.
  19. Functional vitamin B12 deficiency and Alzheimer disease McCaddon, MRCGP; B. Regland, MD, PhD; P. Hudson, MSc; and G. Davies, MSc NEUROLOGY 2002;58:1395-1399
  20. Clinical significance of low cobalamin levels in older hospital patients Dieneke Z. van Asselt , Henk J. Blom , Richard Zuiderent , Ron A. Wevers , Cornelis Jakobs , Wim J. van den Broek , Cornelis B. Lamers , Frans H. Corstens , Willibrord H. Hoefnagels*. The Netherlands Journal of Medicine 2000;57:41-49
  21. Simpson LO. Myalgic encephalomyelitis. Letter. J R Soc Med 1991;84:633.
  22. Lapp CW, Cheney PR. The rationale for using high-dose cobalamine. The CFIDS Chronicle Physicians’ Forum Fall 1993;19-20.
  23. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, Gottfries CG. Scand J Rheumatol. 1997;26(4):301;
  24. Christensen B, Landaas S, Stensvold I, et al. Whole blood folate, homocysteine in serum, and risk of first acute myocardial infarction. Atherosclerosis 1999;147:317-26.
  25. Landgren F, Israelsson B, Lindgren A, et al. Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J Intern Med 1995;237:381-8
  26. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 1996;27:517-27.
  27. Voutilainen S, Lakka TA, Porkkala-Sarataho E, et al. Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr 2000;54:424-8.
  28. Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000;72:324-32.
  29. Clarke R, Armitage J. Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Semin Thromb Hemost 2000;26:341-8.
  30. Paltiel O, Falutz J, Veilleux M, et al. Clinical correlates of subnormal vitamin B12 levels in patients infected with the human immunodeficiency virus. Am J Hematol 1995;49:318-22.
  31. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004;291:565-75.
  32. Carlsen SM, Folling I, Grill V, et al. Metformin increases total homocysteine levels in non-diabetic male patients with coronary heart disease. Scand J Clin Lab Invest 1997;57:521-7.
  33. Dierkes J, Domrose U, Bosselmann P, et al. Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease. J Renal Nutr 2001;11:67-72.
  34. Schnyder G, Roffi M, Flammer Y, et al. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention. The Swiss Heart Study: A randomized controlled trial. JAMA 2002;288:973-9.
  35. Nallamothu BK, Fendrick M, Rubenfire M, et al. Potential clinical and economic effects of homocyst(e)ine lowering. Arch Intern Med 2000;160:3406-12.
  36. van der Dijs FP, Fokkema MR, Dijck-Brouwer DA, et al. Optimization of folic acid, vitamin B12, and vitamin B6 supplements in pediatric patients with sickle cell disease. Am J Hematol 2002;69:239-46.
  37. Selhub J, Jacques PF, Bostom AG, et al. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Publ Health Rev 2000;28:117-45
  38. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57
  39. Shojania AM. Oral contraceptives: effect on folate and vitamin B12 metabolism. Can Med Assoc J 1982;126:244-7
  40. den Heijer M, Brouwer IA, Bos GMJ, et al. Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler Thromb Vasc Biol 1998;18:356-61
  41. Booth GL, Wang EE. Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care. CMAJ 2000;163:21-9
  42. Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 1998;68:1104-10
  43. Bostom AG, Gohh RY, Beaulieu AJ, et al. Treatment of hyperhomocysteinemia in renal transplant recipients. A randomized, placebo-controlled trial. Ann Intern Med 1997;127:1089-92.
  44. Manns B, Hyndman E, Burgess E, et al. Oral vitamin B(12) and high-dose folic acid in hemodialysis patients with hyper-homocyst(e)inemia. Kidney Int 2001;59:1103-9
  45. Clarke R. Prevention of vitamin B-12 deficiency in old age. Am J Clin Nutr. 2001;73:151-152
  46. Duthie SJ, Whalley LJ, Collins AR, et al. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002;75:908-13.
  47. Smith AD. Homocysteine, B vitamins, and cognitive deficit in the elderly. Am J Clin Nutr 2002;75:785-6
  48. Allen LH, Casterline J. Vitamin B-12 deficiency in elderly individuals: diagnosis and requirements. Am J Clin Nutr 1994;60:12-14
  49. Lindenbaum J, Rosenberg IH, Wilson PW, et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
  50. Garcia A, Paris-Pombo A, Evans L, et al. Is low-dose oral cobalamin enough to normalize cobalamin function in older people? J Am Geriatr Soc 2002;50:1401-4.
  51. Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 1997;6:S43-5
  52. Goldin BR, Lichtenstein AH, Gorbach SL. Nutritional and metabolic roles of intestinal flora. In: Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease, 8th ed. Malvern, PA: Lea & Febiger, 1994Carmel R, Green R, Jacobsen DW, et al. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr 1999;70:904-10.
  53. Stabler SP, Allen RH, Fried LP, et al. Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. Am J Clin Nutr 1999;70:911-9
  54. Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720-8
  55. Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness. Br J Nutr 1973;30:277-83
  56. Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 2000;5:93-108
  57. Penninx BW, Guralnik JM, Ferrucci L, et al. Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry 2000;157:715-21
  58. Kuzminski AM, Del Giacco EJ, et al. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 1998;92:1191-1198
  59. Lederle FA. Oral cobalamin for pernicious anemia. Medicine's best kept secret? JAMA 1991;265:94-5
  60. Elia M. Oral or parenteral therapy for B12 deficiency. Lancet 1998;352:1721-2
  61. Andres E, Goichot B, Schlienger JL. Food cobalamin malabsorption: a usual cause of vitamin B12 deficiency. Arch Intern Med 2000;160:2061-2.
  62. Hathcock JN, Troendle GJ. Oral cobalamin for treatment of pernicious anemia? JAMA 1991;265:96-97
  63. Christen WG, Glynn RJ, Chew EY, et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women. Arch Intern Med 2009;169:335-41
  64. Benito-Leon J, Porta-Etessam J. Shaky-leg syndrome and vitamin B12 deficiency. N Engl J Med 2000;342:981
  65. Carpentier JL, Bury J, Luyckx A, et al. Vitamin B12 and folic acid serum levels in diabetics under various therapeutic regimens. Diabete Metab 1976;2:187-90
  66. Zapletal C, Heyne S, Golling M, et al. Influence of selenium therapy on liver microcirculation after warm ischemia/reperfusion: an intravital microscopy study. Transplant Proc 2001;33:974-5
  67. Bauman WA, Shaw S, Jayatilleke E, et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-31
  68. Termanini B, Gibril F, Sutliff VE, et al. Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998;104:422-30
  69. Bellou A, Aimone-Gastin I, De Korwin JD, et al. Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy. J Intern Med 1996;240:161-4
  70. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J Am Coll Nutr 1994;13:584-91
  71. Marcuard SP, Albernaz L, Khazaine PG. Omeprazole therapy causes malabsorption of cyanocobalamin. Ann Intern Med 1994;120:211-5.
  72. Bauman WA, Spungen AM, Shaw S, et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-31.
  73. Ruscin JM, Page RL, Valuck RJ. Vitamin B12 deficiency associated with histamine-2-receptor antagonists and a proton-pump inhibitor. Ann Pharmacother 2002;36:812-6
  74. Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams & Wilkins, 1999
  75. Fauci AS, Braunwald E, Isselbacher KJ, et al. Harrison's Principles of Internal Medicine, 14th ed. New York, NY: McGraw-Hill, 1998
  76. Palva IP, Salokannel SJ, Timonen T, et al. Drug-induced malabsorption of vitamin B12. IV. Malabsorption and deficiency of B12 during treatment with slow-release potassium chloride. Acta Med Scand 1972;191:355-7
  77. Salokannel SJ, Palva IP, Takkunen JT, et al. Malabsorption of vitamin B12 during treatment with slow-release potassium chloride. Preliminary report. Acta Med Scand 1970;187:431-2
  78. Palva IP, Salokannel SJ, Palva HLA, et al. Drug-induced malabsorption of vitamin B12. VII Malabsorption of B12 during treatment with potassium citrate. Acta Med Scand 1974;196:525-6.
  79. Herbert V, Jacob E. Destruction of vitamin B12 by ascorbic acid. JAMA 1974;230:241-2
  80. Yamadera W, Sasaki M, Itoh H, et al. Clinical features of circadian rhythm sleep disorders in outpatients. Psychiatry Clin Neurosci 1998;52:311-6
  81. Okawa M, Uchiyama M, Ozaki S, et al. Circadian rhythm sleep disorders in adolescents: clinical trials of combined treatments based on chronobiology. Psychiatry Clin Neurosci 1998;52:483-90
  82. Okawa M, Takahashi K, Egashira K, et al. Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study. Psychiatry Clin Neurosci 1997;51:275-9.
  83. Yamadera H, Takahashi K, Okawa M. A multicenter study of sleep-wake rhythm disorders: therapeutic effects of vitamin B12, bright light therapy, chronotherapy and hypnotics. Psychiatry Clin Neurosci 1996;50:203-9
  84. Ohta T, Ando K, Iwata T, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep 1991;14:414-8
  85. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at:http://books.nap.edu/books/0309065542/html/.
  86. Tremblay R, Bonnardeaux A, Geadah D, et al. Hyperhomocystinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins. Kidney Int 2000;58:851-8
  87. Beaulieu AJ, Gohh RY, Han H, et al. Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients. Arterioscler Thromb Vasc Biol 1999;19:2918-21
  88. Deutch B, Jorgensen EB, Hansen JC. n-3 PUFA from fish or seal oil reduce atherogenic risk indicators in Danish women. Nutr Res 2000;20:1065-77.
  89. Marie RM, Le Biez E, Busson P, et al. Nitrous-oxide anesthesia-associated myelopathy. Arch Neurol 2000;57:380-2.
  90. Bostom A, Shemin D, Gohh R, et al. Treatment of mild hyperhomocysteinemia in renal transplant recipients versus hemodialysis patients. Transplantation 2000;69:2128-31
  91. Seal EC, Metz J, Flicker L, Melny J. A randomized, double-blind, placebo-controlled study of oral vitamin B12 supplementation in older patients with subnormal or borderline serum vitamin B12 concentrations. J Am Geriatr Soc 2002;50:146-51.
  92. Bostom AG, Shemin D, Gohh RY, et al. Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients. Kidney Int 2001;59:s246-s252
  93. Stucker M, Pieck C, Stoerb C, et al. Topical vitamin B12 - a new therapeutic approach in atopic dermatitis - evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dematol 2004;150:977-83
  94. Tyrer LB. Nutrition and the pill. J Reprod Med 1984;29:547-50.
  95. Andres E, Kurtz JE, Perrin AE, et al. Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption. Am J Med 2001;111:126-9
  96. Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. BMJ 1998;316:894-8
  97. http://www.mlds.nl/ziekten/59/pernicieuze-anemie/
  98. Castelli MC, Friedman K, [..], Riley MG. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther 2011; 33(3):358-71).
  99. Eussen SJ, de Groot LC, Clarke R, Schneede J,Ueland PM, Hoefnagels WH, van Staveren WA. Oral Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency A Dose-inding Trial. Arch Intern Med. 2005 May 23;165(10):1167-72)