Hoge zoutinname bevordert auto-immuunziekten

Een hoge zoutinname verhoogt de kans op (verergering van) hypertensie, hart- en vaatziekten (waaronder beroerte) en nierziekte, en is geassocieerd met een verhoogde sterftekans.1,2 Wetenschappers doen de laatste jaren veel onderzoek naar de effecten van een hoge zoutinname op het immuunsysteem. Inmiddels is er toenemend wetenschappelijk bewijs uit preklinische en enige klinische studies dat een hoge zoutinname niet alleen pro-inflammatoire effecten heeft, maar ook bij mensen met genetische predispositie de ontwikkeling en progressie van auto-immuunziekten bevordert. Essentiële hypertensie is mogelijk ook een auto-immuunziekte.3

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Auteur

Selma Timmer

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Referenties

  1. Sharif K et al. The role of dietary sodium in autoimmune diseases: The salty truth. Autoimmun Rev. 2018;17(11):1069-1073.

  2. Wilck N et al. The role of sodium in modulating immune cell function. Nat Rev Nephrol. 2019;15(9):546-558.

  3. Solak Y et al. Hypertension as an autoimmune and inflammatory disease. Hypertens Res. 2016;39:567-573.

  4. Lee GR. The balance of Th17 versus Treg cells in autoimmunity. Int J Mol Sci. 2018;19:730.

  5. Brown IJ et al. Salt intakes around the world: implications for public health. Int J Epidemiol 2009;38:791–813.

  6. Guideline: sodium intake for adults and children. Geneva: World Health Organization 2012. http://www.ncbi.nlm.nih.gov/books/NBK133309/

  7. He FJ, Jenner KH, Macgregor GA. WASH-world action on salt and health. Kidney Int. 2010;78:745-53.

  1. Sigaux J et al. Salt, inflammatory joint disease, and autoimmunity. Joint Bone Spine. 2018;85(4):411-416.

  2. Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013;496:518-22.

  3. Wu C, Yosef N, Thalhamer T, et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 2013;496:513-7.

  4. Ip WK et al. Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun. 2015;6:6931.

  5. Hernandez AL et al. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest 2015;125:4212-22.

  6. Abdel-Moneim A et al. The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus. Biomed Pharmacother. 2018;101:287-292.

  7. Miedema JR et al. Th17-lineage cells in pulmonary sarcoidosis and Löfgren's syndrome: Friend or foe? J Autoimmun. 2018;87:82-96.

  8. Müller S et al. Salt-dependent chemotaxis of macrophages. PloS One 2013;8:e73439.

  9. Zhang WC et al. High salt primes a specific activation state of macrophages, M(Na). Cell Res 2015;25:893-910.

  10. Binger KJ et al. High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest 2015;125(11):4223–38.

  11. Yi B et al. Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study. Transl Res J Lab Clin Med. 2015;166:103-10.

  12. Farez MF et al. Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 2015;86:26-31.

  13. Sundström B et al. Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case-control study. Rheumatol Oxf Engl. 2015;54:487-93.

  14. Salgado E et al. High sodium intake is associated with self-reported rheumatoid arthritis: a cross sectional and case control analysis within the SUN cohort. Medicine (Baltimore) 2015;94:e924.

  15. Jiang Xet al. High sodium chloride consumption enhances the effects of smoking but does not interact with SGK1 polymorphisms in the development of ACPA-positive status in patients with RA. Ann Rheum Dis. 2016;75(5):943-6.

  16. Wu H et al. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells. Sci Rep 2016;6:28065.

  17. Yang X et al. Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway. Int Immunopharmacol 2015;29:568-73.

  18. Wei Y et al. High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice. Oncotarget 2017;8:70-82.

  19. Monteleone I et al. Sodium chloride-enriched diet enhanced inflammatory cytokine production and exacerbated experimental colitis in mice. J Crohns Colitis 2017;11:237-45.

  20. Khalili H et al. Identification and characterization of a novel association between dietary potassium and risk of Crohn’s disease and ulcerative colitis. Front Immunol 2016;7:554.

  21. Wen W et al. Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. Exp Mol Pathol 2016;100:370-7.

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