Melatonine, een endogeen indoleamine geproduceerd door de epifyse, is een chronobiologisch hormoon, maar heeft ook krachtige antioxidant-, anti-inflammatoire en cytoprotectieve, naast antihypertensieve, anxiolytische en sedatieve eigenschappen.
De laatste jaren is er tevens veel onderzoek gedaan naar de pijnstillende effecten van melatonine. In experimentele studies blijkt melatonine krachtige, dosisdependente analgetische eigenschappen te hebben. In klinische studies is melatonine effectief bij chronische pijnpatiënten (fibromyalgie, IBS, migraine, depressie). Herhaalde toediening van melatonine verbetert bovendien de slaap, en hierdoor ook de angst, wat het pijnniveau ook verlaagt.
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Tox
Seabra ML, Bignotto M, Pinto LR, Tufik S. Randomized double blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 2000;29;193-200. |
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88 | Seabra ML, Bignotto M, Pinto LR, Tufik S. Randomized double blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 2000;29;193-200. |
89 | Weishaupt JH, Bartels C, Polking E, Dietrich J, Rohde G, Poeggeler B, et al. Reduced oxidative damage in ALS by high- dose enteral melatonin treatment. J Pineal Res 2006;41:313-23. |
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| Citera G, Arias MA, Maldonado-Cocco JA, Lázaro MA, Rosemffet MG, Brusco LI, et al. The effect of melatonin in patients with fibromyalgia: A pilot study. Clin Rheumatol 2000;19:9-13. |
88 | Seabra ML, Bignotto M, Pinto LR, Tufik S. Randomized double blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 2000;29;193-200. |
89 | Weishaupt JH, Bartels C, Polking E, Dietrich J, Rohde G, Poeggeler B, et al. Reduced oxidative damage in ALS by high- dose enteral melatonin treatment. J Pineal Res 2006;41:313-23. |
