Fysiologische adaptatie bij stressbelasting is een fenomeen dat ondersteund kan worden met behulp van moleculen uit moeder Natuur. Adaptogenen in de vorm van gestandaardiseerde kruidenextracten kunnen een ‘staat van niet-specifieke weerstand’ tot stand brengen gericht tegen stressoren. Uit studies is gebleken dat adaptogenen bescherming kunnen bieden gericht tegen depressiviteit, angstbeleving, fysieke vermoeidheid en neurologische overbelasting. Deze werkzaamheid kan deels verlopen via modulerende werking van de hormoonassen bij herstel van de homeostase.1 De medicinale toepassing van zoethoutwortel (Glycyrrhiza glabra) is een voorbeeld van adaptogene beïnvloeding middels hormonale modulatie.
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Panossian A and Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals 3: 188-224, 2010
Lee MR. Liquorice (Glycyrrhiza glabra): the journey of the sweet root from Mesopotamia to England. J R Coll Physicians Edinb 48: 378–82, 2018
Yang R, Li W, Yuan B, Ma Y, Zhou S, et al. Simultaneous determination of 18 α-glycyrrhizic acid and 18 β-glycyrrhizic acid in three licorice samples from different origin by HPLC. Chin J Pharm Anal 36: 1065-1071, 2016
Al-Snafi AE. Glycyrrhiza glabra: A phytochemical and pharmacological review IOSR Journal Of Pharmacy 8(6) Version I: 01-17, 2018
Mills S and Bone K. Principles and Practices of Phytotherapy. Churchill Livingstone, 2010
Lin D et al. Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. Journal of Biomedicine and Biotechnology Volume 2012
Mackenzy MA et al. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab. 1990 Jun;70(6):1637-43
Yang R et al. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharmaceutical Biology 55(1): 5-18, 2017
Su XS, Chen HM, Wang LH, et al. Clinical and laboratory observation on the effect of glycyrrhizin in acute and chronic viral hepatitis. J Tradit Chin Med 4: 127-132, 1984
Baba M, Shigeta S. Antiviral activity of glycyrrhizin against Varicella-zoster virus in vitro. Antiviral Res 7: 99-107, 1987
Ito M, Sato A, Hirabayashi K, et al. Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Antiviral Res 10: 289-298, 1988
Pompei R, Flore O, Marccialis MA, et al. Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature 281: 689-690, 1979
E.A.S. Al-Dujaili, C.J. Kenyon, M.R. Nicol, J.I. Mason. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels by inhibiting adrenal SULT2Aactivity. Molecular and Cellular Endocrinology, Elsevier 336 (1-2), 102, 2011
Russell DW, Wilson JD. Steroid 5α-reductase: two genes/two enzymes. Ann Rev Biochem. 63:25–61, 1994
Armanini D et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes 111(6): 341-3, 2003
Armanini D et al. Licorice reduces serum testosterone in healthy women. Steroids. 69(11-12): 763-6, 2004
Fukui M et al. Glycyrrhizin and Serum Testosterone Concentrations in Male Patients With Type 2 Diabetes. Diabetes Care 26(10), 2003
Armanini D et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes. 111(6): 341-3, 2003
Powers CN, Setzer WN. A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements. In Silico Pharmacology 3:4, 2015
Simons R et al. Agonistic and antagonistic estrogens in licorice root. Anal Bioanal Chem 401: 305–313, 2011
Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen S-N, et al. Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms. PLoS ONE 8(7), 2013
Tamir S et al. Estrogenic and Antiproliferative Properties of Glabridin from Licorice in Human Breast Cancer Cells. Cancer Research 60: 5704–5709, 2000
Rybacyk LA et al. An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology. BMC Women's Health 5(12), 2005
Dingra D, Sharma A. Evaluation of antidepressant-like activity of glycyrrhizin in mice. Indian J of Pharmacol. 37(6): 390-394, 2005
Hatano T, Fukuda T, Miyase T, Noro T, Okuda T (1991) Phenolic constituents of licorice, part III. Chem Pharm Bull. 39(5): 1238-43, 1991
Cui M, Ming-Zhang Ao, Wei Li , Long-Jiang Yu. Effect of Glabridin from Glycyrrhiza glabra on Learning and Memory in Mice. Planta Med 74(4): 377-380, 2008
Simmler Ch , Pauli GF, and Chen SN. Phytochemistry and Biological Properties of Glabridin. Fitoterapia 0: 160–184, 2013
Glycyrrhiza glabra, Monograph. Alternative Medicine Review 10(3), 2005 Panossian A and Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals 3: 188-224, 2010
Lee MR. Liquorice (Glycyrrhiza glabra): the journey of the sweet root from Mesopotamia to England. J R Coll Physicians Edinb 48: 378–82, 2018
Yang R, Li W, Yuan B, Ma Y, Zhou S, et al. Simultaneous determination of 18 α-glycyrrhizic acid and 18 β-glycyrrhizic acid in three licorice samples from different origin by HPLC. Chin J Pharm Anal 36: 1065-1071, 2016
Al-Snafi AE. Glycyrrhiza glabra: A phytochemical and pharmacological review IOSR Journal Of Pharmacy 8(6) Version I: 01-17, 2018
Mills S and Bone K. Principles and Practices of Phytotherapy. Churchill Livingstone, 2010
Lin D et al. Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats. Journal of Biomedicine and Biotechnology Volume 2012
Mackenzy MA et al. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab. 1990 Jun;70(6):1637-43
Yang R et al. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharmaceutical Biology 55(1): 5-18, 2017
Su XS, Chen HM, Wang LH, et al. Clinical and laboratory observation on the effect of glycyrrhizin in acute and chronic viral hepatitis. J Tradit Chin Med 4: 127-132, 1984
Baba M, Shigeta S. Antiviral activity of glycyrrhizin against Varicella-zoster virus in vitro. Antiviral Res 7: 99-107, 1987
Ito M, Sato A, Hirabayashi K, et al. Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Antiviral Res 10: 289-298, 1988
Pompei R, Flore O, Marccialis MA, et al. Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature 281: 689-690, 1979
E.A.S. Al-Dujaili, C.J. Kenyon, M.R. Nicol, J.I. Mason. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels by inhibiting adrenal SULT2Aactivity. Molecular and Cellular Endocrinology, Elsevier 336 (1-2), 102, 2011
Russell DW, Wilson JD. Steroid 5α-reductase: two genes/two enzymes. Ann Rev Biochem. 63:25–61, 1994
Armanini D et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes 111(6): 341-3, 2003
Armanini D et al. Licorice reduces serum testosterone in healthy women. Steroids. 69(11-12): 763-6, 2004
Fukui M et al. Glycyrrhizin and Serum Testosterone Concentrations in Male Patients With Type 2 Diabetes. Diabetes Care 26(10), 2003
Armanini D et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes. 111(6): 341-3, 2003
Powers CN, Setzer WN. A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements. In Silico Pharmacology 3:4, 2015
Simons R et al. Agonistic and antagonistic estrogens in licorice root. Anal Bioanal Chem 401: 305–313, 2011
Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen S-N, et al. Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms. PLoS ONE 8(7), 2013
Tamir S et al. Estrogenic and Antiproliferative Properties of Glabridin from Licorice in Human Breast Cancer Cells. Cancer Research 60: 5704–5709, 2000
Rybacyk LA et al. An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology. BMC Women's Health 5(12), 2005
Dingra D, Sharma A. Evaluation of antidepressant-like activity of glycyrrhizin in mice. Indian J of Pharmacol. 37(6): 390-394, 2005
Hatano T, Fukuda T, Miyase T, Noro T, Okuda T (1991) Phenolic constituents of licorice, part III. Chem Pharm Bull. 39(5): 1238-43, 1991
Cui M, Ming-Zhang Ao, Wei Li , Long-Jiang Yu. Effect of Glabridin from Glycyrrhiza glabra on Learning and Memory in Mice. Planta Med 74(4): 377-380, 2008
Simmler Ch , Pauli GF, and Chen SN. Phytochemistry and Biological Properties of Glabridin. Fitoterapia 0: 160–184, 2013
