De herwaardering van vitamine B6

Vitamine B6 is in de afgelopen jaren ten onrechte in diskrediet geraakt. Huisartsen wijzen op de gevaren van een te hoge bloedspiegel van vitamine B6, met name in relatie tot het ontwikkelen van polyneuropathie. Maar is dat terecht? Of was de oorzaak van de commotie over B6 – o.a. door een artikel in de Volkskrant van twee jaar geleden over Sven Kramer en B6 gerelateerde neuropathie – wetenschappelijk onjuist. Dit artikel is een wetenschappelijke opsomming over de veiligheid en de functionaliteit van vitamine B6.

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Auteur

Dirk Zoutewelle

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Referenties

  1. Vrolijk, M. F. et al: The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicology in Vitro 44 (2017) 206–212

  2. Lareb, B.C.. Meldingen van bijwerkingen van warenwetmiddelen. 2015

  3. Bernstein, A. L. Vitamin B6 in clinical neurology. Annals of the New York Academy of Sciences, 1990. 585(1), 250-260.

  4. Kulkantrakorn, K. Pyridoxine-induced sensory ataxic neuronopathy and neuropathy: revisited. Neurological Sciences, 2014. 35(11), 1827-1830.

  5. Katan, M. B. How much vitamin B6 is toxic?. Nederlands tijdschrift voor geneeskunde, 2005. 149(46), 2545-2546.

  6. Simpson, J.L., et al: Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part II–vitamin D, vitamin A, iron, zinc, iodine, essential fatty acids. J. Matern. Fetal Neonatal Med. 2011. 1, 1–24.

  7. Ueland, P.M., et al: Direct and functional biomarkers of vitamin B6 status. Annu. Rev. Nutr. 2015. 35, 33–70.

  8. Eliot, A.C., Kirsch, J.F. Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations. Annu. Rev. Biochem. 2014. 73, 383–415.

  9. Percudani, R., Peracchi, A. The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families. BMC Bioinf. 2009. 10, 273.

  10. Zuo, H., et al: Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland health study. Int. J. Cancer 2015. 136 (12), 2932–2939.

  11. Albersen, M., et al:. Vitamin B6 in plasma and cerebrospinal fluid of children. PLoS One 2015. 10 (3), e0120972.

  12. Spinneker, A., et al:. Vitamin B6 status, deficiency and its consequences–an overview. Nutr. Hosp. 2007. 22 (1), 7–24.

  13. Ulvik, A., et al: Long- and short-term effects of tobacco smoking on circulating concentrations of B vitamins. Clin. Chem 2010. 56 (5), 755-763.

  14. da Silva, V.R., et al: Vitamin B6. In: Present Knowledge in Nutrition. Wiley-Blackwell, New York. 2012

  15. di Salvo, M.L., et al: Biomedical aspects of pyridoxal 5′- phosphate availability. Front. Biosci. 2012. 4, 897–913.

  16. Buchet, R., et al:. Multisystemic functions of alkaline phosphatases. Methods Mol. Biol 2013. 1053, 27e51.

  17. Carter, T.C. et al. Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5-Phosphate Concentration in Healthy Adults. The Journal of Nutrition. First published online May 13, 2015; doi:10.3945/jn.114.208769

  18. Hinz, M., Stein, A., Cole, T. The Parkinson’s disease death rate: carbidopa and vitamin B6. Clinical Pharmacology: Advances and Applications 2014:6 161–169

  19. Cheng, C.H., et al. Plasma pyridoxal 50-phosphate and high-sensitivity c-reactive protein are independently associated with an increased risk of coronary artery disease. Nutrition 2008. 24 (3), 239e244.

  20. Vanuzzo, D., et al. Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects. Eur. Heart J. 2007. 28 (4), 484e491

  21. Hron, G., et al. Low vitamin B6 levels and the risk of recurrent venous thromboembolism. Hematol. J. 2007. 92 (9), 1250e1253.

  22. Tavani, A., et al. Folate and vitamin B-6 intake and risk of acute myocardial infarction in italy. Eur. J. Clin. Nutr 2004. 58, 1266e1272.

  23. Wu, W. et al. Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis. Br. J.Cancer 2013. 109 (7), 1926e1944.

  24. Zhang, X.H. et al. Vitamin B6 and colorectal cancer: current evidence and future directions. World J. Gastroenterol 2013. 19 (7), 1005e1010

  25. Larsson, S.C., et al. Vitamin B-6 and risk of colorectal cancer. A meta-analysis of prospective studies. JAMA 2010. 303 (11), 1077e1083.

  26. Eussen, S., et al. Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol. Biomarkers Prev 2010. 19(1), 28e38.

  27. Johansson, M., et al. Serum B vitamin levels and risk of lung cancer. JAMA 2010. 03 (23),2377e2385.

  28. Lee, J.E., et al. Prospective study of plasma vitamin B-6 and risk of colorectal cancer in men. Cancer Epidemiol. Biomarkers Prev 2009. 18 (4), 1197e1202

  29. Theodoratou, E., et al. Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol. Biomarkers Prev 2008. 17 (1), 171e182.

  30. Selhub, J., et al. Dietary vitamin B6 intake modulates colonic inflammation in the IL10(/) model of inflammatory bowel disease. J. Nutr. Biochem 2013. 24 (12), 2138e2143

  31. Huang, S.C., et al. Vitamin B-6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur. J. Clin. Nutr 2010. 64 (9), 1007e1013

  32. Chiang, E.P., et al. Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res. Ther 2005. 7 (6), R1254eR1262.

  33. Friedman, A.N., Clinical and nutritional correlates of c-reactive protein in type 2 diabetic nephropathy. Atherosclerosis 2004. 172 (1), 121e125.

  34. Zhang, X.H. et al. Vitamin B6 and colorectal cancer: current evidence and future directions. World J. Gastroenterol 2013. 19 (7), 1005e1010

  35. Tan, B.K., et al. Omentin: a novel llnk between inflammation, diabesity, and cardiovascular disease. Trends Cardiovasc. Med 2010. 20 (5),143e148.

  36. Page, J.H., et al. Plasma vitamin B-6 and risk of myocardial infarction in women. Circulation 2009. 120(8), 649e655.

  37. Visser, N. A., et al: Chronic idiopathic axonal polyneuropathy and vitamin B6: a controlled population-based study. Journal of the Peripheral Nervous System 2014 19:136–144

  38. Dietary Reference Values for Vitamin B6. EFSA Journal 2016;14(6):4485

  39. www.rivm.nl/Documenten_en_publicaties/Algemeen_Actueel/Nieuwsberichten/2.... 2013

  40. Tucker et al: Am J Clin Nutr 2005;82:627-635

  41. Kelly P.J. et al: Stroke 2003;34:e51-e54

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