Vitamine B12, even belangrijk als folaat?
De sniper onder de voedingsdeficiënties

Tekorten aan vitamine B12 of cobalamine waren vroeger zeer gevreesd als oorzaak van pernicieuze anemie, zo genoemd omdat deze meestal fataal afliep vóór de behandeling met leverextracten, en later B12 bekend was. De vitamine werd in 1947 geïsoleerd uit lever (extracten werden al langer gebruikt in de behandeling).
Vitamine B12 speelt een centrale rol bij de vorming van bloedcellen, maar ook in ontwikkeling en functie van hersenen en zenuwstelsel. Daarnaast komt het als co-enzym ook tussen in de folaat-methyleringscyclus, dus DNA-synthese en werking, lipiden- en aminozuurmetabolisme, én in de mitochondriale energieproductie.

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Auteur

Marleen Nys

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  1. Dali-Youcef N, Andrès E. An update on cobalamin deficiency in adults. QJM 2008; 102(1)17-28.

  2. Andrès E et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. Aug 3, 2004; 171(3): 251–259.

  3. Imerslund O. Idiopathic chronic megaloblastic anemia in children. Acta Paediatr Suppl 1960;49 Suppl 119:1-115.

  4. Grasbeck R. Familiar selective vitamin B12 malabsorption with proteinuria. A pernicious anemia-like syndrome. Nord Med 1960;63:322-3.

  5. Ray JG et al. High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification. QJM. 2008 Jun;101(6):475-7.

  6. Watanabe F et al. Vitamin B₁₂-containing plant food sources for vegetarians. Nutrients 2014 5;6(5):1861-73.

  7. Watanabe F et al. Pseudovitamin B(12) is the predominant cobamide of an algal health food, spirulina tablets. J Agric Food Chem 1999 Nov;47(11):4736-41.

  8. Watanabe F, Bito T et al. Biologically active vitamin B12 compounds in foods for preventing deficiency among vegetarians and elderly subjects. J Agric Food Chem 2013 Jul 17;61(28):6769-75.

  9. Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull. 2008 Jun;29(2 Suppl):S20-34; discussion S35-7.

  10. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009 Feb;89(2):693S-6S.

  11. Andres E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004;171:251-9.

  12. Leishker AH, Kolb GF. Vitamin B12 deficiency in the elderly.] Z Gerontol Geriatr. 2015 Jan 14. [Epub ahead of print]

  13. Mézière A et al. B12 deficiency increases with age in hospitalized patients: a study on 14,904 samples. J Gerontol A Biol Sci Med Sci. 2014 Dec;69(12):1576-85.

  14. Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature.

  15. Woo KS et al. Vegan diet, subnormal vitamin B-12 status and cardiovascular health. Nutrients. 2014 Aug 19;6(8):3259-73.

  16. Affenberger S, Vinzio S, Kurtz JE, Noel E, Kaltenbach G, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med 2005;118:1154-9.

  17. Jung SB et al. The Association Between Vitamin B12 Deficiency and Long-Term Use of Acid Lowering Agents: A Systematic Review and Meta-Analysis. Intern Med J. 2015 Jan 13. [Epub ahead of print]

  18. Lam JR et al. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013 Dec 11;310(22):2435-42.

  19. Carmel R, Aurangzeb I, Qian D. Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. Am J Gastroenterol 2001;96:63-70.

  20. Jensen RT. Consequences of long-term proton pump blockade: insights from studies of patients with gastrinomas. Basic Clin Pharmacol Toxicol 2006;98:4-19.

  21. Andres E, Noel E, Abdelghani MB. Vitamin B(12) deficiency associated with chronic acid suppression therapy. Ann Pharmacother 2003;37:1730.

  22. Howden CW. Vitamin B12 levels during prolonged treatment with proton pump inhibitors. J Clin Gastroenterol 2000;30:29-33.

  23. Anitha P et al. Vitamin B12 deficiency presenting as pancytopenia and retinopathy in a young boy-Helicobacter pylori, a novel causative agent. Australas Med J. 2014 Mar 31;7(3):143-8.

  24. Sarari AS et al. Helicobacter pylori, a causative agent of vitamin B12 deficiency. J Infect Dev Ctries. 2008 Oct 1;2(5):346-9.

  25. Kang D et al. Higher prevalence of metformin-induced vitamin B12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study. PLoS One. 2014 Oct 9;9(10):e109878.

  26. Ko SH et al. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. J Korean Med Sci. 2014 Jul;29(7):965-72.

  27. Sato Y et al. Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. Endocr J. 2013;60(12):1275-80.

  28. Beulens JW, Hart HE, Kuijs R, Kooijman-Buiting AM, Rutten GE. Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol. 2014 Jun 8. [Epub ahead of print]

  29. De Jager J, Stehouwer CDA et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. 2010 BMJ 340: c2181

  30. Andrès E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency. Arch Intern Med 2002; 162 (19): 2251–2.

  31. Jean W. Metformin-related vitamin B12 deficiency. Age Ageing 2006;35:200-1.

  32. Gilligan M. Metformin and vitamin B12 deficiency. Arch Intern Med 2002; 162 (4): 484–5.

  33. Bauman WA, Shaw S, Jayatilleke E, Spungen AM, Herbert V. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-31.

  34. Battat R et al. Vitamin B12 deficiency in inflammatory bowel disease: prevalence, risk factors, evaluation, and management. Inflamm Bowel Dis. 2014 Jun;20(6):1120-8.

  35. Andres E, Goichot B, Perrin AE, Vinzio S, Demangeat C, Schlienger JL. Sjogren's syndrome: a potential new aetiology of mild cobalamin deficiency. Rheumatology 2001;40:1196-7.

  36. Gérard M et al. Multiple Congenital Anomalies in two Boys with Mutation in HCFC1 and Cobalamin Disorder. Eur J Med Genet. 2015 Jan 13. [Epub ahead of print]

  37. Yu HC et al. An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1. Am J Hum Genet. 2013 Sep 5;93(3):506-14.

  38. Farwell Gonzalez KD et al. Diagnostic Exome Sequencing and Tailored Bioinformatics of the Parents of a Deceased Child with Cobalamin Deficiency Suggests Digenic Inheritance of the MTR and LMBRD1 Genes. JIMD Rep. 2015;15:29-37.

  39. Atkinson C1, Miousse IR, Watkins D, Rosenblatt DS, Raiman JA. Clinical, Biochemical, and Molecular Presentation in a Patient with the cblD-Homocystinuria Inborn Error of Cobalamin Metabolism. JIMD Rep. 2014;17:77-81.

  40. Carmel R. Mild transcobalamin I (haptocorrin) deficiency and low serum cobalamin concentrations. Clin Chem 2003;49:1367-74.

  41. Tanner SM, Li Z, Perko JD, Oner C, Cetin M, Altay C, et al. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. Proc Natl Acad Sci USA 2005;102:4130-3.

  42. Kristiansen M, Aminoff M, Jacobsen C, de La Chapelle A, Krahe R, Verroust PJ, et al. Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin. Blood 2000;96:405-9.

  43. Teplitsky V, Huminer D, Zoldan J, Pitlik S, Shohat M, Mittelman M. Hereditary partial transcobalamin II deficiency with neurologic, mental and hematologic abnormalities in children and adults. Isr Med Assoc J 2003;5:868-72

  44. Christensen EI, Birn H. Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 2002;3:256-66.

  45. Kozyraki R, Kristiansen M, Silahtaroglu A, Hansen C, Jacobsen C, Tommerup N, et al. The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 1998;91:3593-600.

  46. Fyfe JC, Madsen M, Hojrup P, Christensen EI, Tanner SM, de la Chapelle A, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 2004;103:1573-9

  47. Lonn E, Yusuf S, Arnold MJ, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. NEJM 2006354 (15): 1567–77.

  48. Loukili NH, Noel E, Blaison G, Goichot B, Kaltenbach G, Rondeau M, et al. Update of pernicious anemia. A retrospective study of 49 cases. Rev Med Interne 2004;25:556-61.

  49. Bizzaro N, Antico A. Autoimmun Diagnosis and classification of pernicious anemia. Rev. 2014 Apr-May;13(4-5):565-8.

  50. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006;5:949-60.

  51. Dharmarajan TS, Adiga GU, Norkus EP. Vitamin B12 deficiency. Recognizing subtle symptoms in older adults. Geriatrics 2003;58:30-4. 7–8.

  52. Carmel R, Sarrai M. Diagnosis and management of clinical and subclinical cobalamin deficiency: advances and controversies. Curr Hematol Rep 2006;5:23-

  53. Andres E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol 2006;28:50-6.

  54. Wickramasinghe SN. Diagnosis of megaloblastic anaemias. Blood Rev 2006;20:299-318.

  55. Andres E, Perrin AE, Kraemer JP, Goichot B, Demengeat C, Ruellan A, et al. Anemia caused by vitamin B 12 deficiency in subjects aged over 75 years: new hypotheses. A study of 20 cases. Rev Med Interne 2000;21:946-54.

  56. Routh JK, Koenig SC. Severe vitamin B12 deficiency mimicking thrombotic thrombocytopenic purpura. Blood 2014 Sep 11;124(11):1844.

  57. GruberJF, Cottingham KL et al. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutrition Journal, 2012; 11:45  doi:10.1186/1475-2891-11-45

  58. Bjelakovic G, Pavlović D, Jevtovic T, Stojanovic I, Sokolovic D, Bjelakovic G, et al. Vitamin B12 and folic acid effects on polyamine metabolism in rat liver. Pteridines. 2006;17:90–4.

  59. Solomon LR. Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress. Eur J Clin Nutr. 2015 Jan 7. [Epub ahead of print]

  60. Kumar N. Neurologic aspects of cobalamin (B12) deficiency. Handb Clin Neurol. 2014;120:915-26.

  61. Reynolds EH. The neurology of folic acid deficiency. Handb Clin Neurol. 2014;120:927-43.

  62. Cosar A et al. Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry. Turk J Med Sci 2014;44(1):1-9.

  63. Biemans E et al. Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin. Acta Diabetol. 2014 Oct 15. [Epub ahead of print]

  64. de Souza A, Moloi MW. Involuntary movements due to vitamin B12 deficiency. Neurol Res. 2014 Dec;36(12):1121-8.

  65. Kibirige D, Wekesa C, Kaddu-Mukasa M, Waiswa M. Vitamin B12 deficiency presenting as an acute confusional state: a case report and review of literature. Afr Health Sci. 2013 Sep;13(3):850-2. (44 j)

  66. Rahmandar MH et al. Cobalamin C deficiency in an adolescent with altered mental status and anorexia. Pediatrics. 2014 Dec;134(6):e1709-14

  67. Mavrommati K, Sentissi O. Delirium as a result of vitamin B12 deficiency in a vegetarian female patient. Eur J Clin Nutr. 2013 Sep;67(9):996-7.

  68. de Jager CA. Critical levels of brain atrophy associated with homocysteine and cognitive decline. Neurobiol Aging. 2014 Sep;35 Suppl 2:S35-9.

  69. Sezgin Z, Dincer Y. Alzheimer's disease and epigenetic diet. Neurochem Int. 2014 Dec;78:105-16.

  70. Chen H et al. Associations between Alzheimer's Disease and Blood Homocysteine, Vitamin B12, and Folate: A Case-Control Study. Curr Alzheimer Res. 2015;12(1):88-94.

  71. Pott JW, Wong KH. Leber's hereditary optic neuropathy and vitamin B12 deficiency". Graefe's Arch Clin Exper Ophthalmol 2006; 244(10): 1357–9.

  72. Demir N et al. Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms. Cutan Ocul Toxicol. 2014 Mar;33(1):70-3.

  73. Brescoll J, Daveluy S. A Review of Vitamin B12 in Dermatology. Am J Clin Dermatol. 2015 Jan 6. [Epub ahead of print]

  74. Gatford KL et al. Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. Obes Metab 2013 Jul;15(7):660-7.

  75. Kocaoglu C, Akin F, Caksen H, Böke SB, Arslan S, Aygün S. Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother. J Health Popul Nutr. 2014 Jun;32(2):367-71.

  76. Pietrzyk JJ, Bik-Multanowski M. 776C>G polymorphism of the transcobalamin II gene as a risk factor for spina bifida. Mol Genet Metab. 2003 Nov;80(3):364

  77. Gueant JL, Gueant-Rodriguez RM, Anello G, Bosco P, Brunaud L, Romano C, Ferri R, Romano A, Candito M, Namour B. Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome? Clin Chem Lab Med. 2003 Nov;41(11):1473-7.

  78. van Rooij IA, Swinkels DW, Blom HJ, Merkus HM, Steegers-Theunissen RP. Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol. 2003 Oct;189(4):1155-60.

  79. Suarez L, Hendricks K, Felkner M, Gunter E. Maternal serum B12 levels and risk for neural tube defects in a Texas-Mexico border population. Ann Epidemiol. 2003 Feb;13(2):81-8

  80. Gueant-Rodriguez RM, Rendeli C, Namour B, Venuti L, Romano A, Anello G, Bosco P, Debard R, Gerard P, Viola M, Salvaggio E, Gueant JL. Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett. 2003 Jul 3;344(3):189-92.

  81. Demir N, Koc A, Üstyol L, Peker E, Abuhandan M. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child Health. 2013 Oct;49(10):820-4.

  82. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G, Yadav VK. Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass. J Clin Invest. 2014 Jul 1;124(7):2988-3002.

  83. Krueger JM et al. A treatable metabolic cause of encephalopathy: cobalamin C deficiency in an 8-year-old male. Pediatrics. 2015 Jan;135(1):e202-6.

  84. Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL. Oral cobalamin remains medicine's best kept secret. Arch Gerontol Geriatr 2007;44:49-59

  85. Aparicio-Ugarriza R, Palacios G, Alder M, González-Gross M. A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population. Clin Chem Lab Med. 2014 Dec 3. [Epub ahead of print]

  86. Andres E, Kaltenbach G, Noel E, Noblet-Dick M, Perrin AE, Vogel T, et al. Efficacy of short-term oral cobalamin therapy for the treatment of cobalamin deficiencies related to food-cobalamin malabsorption: a study of 30 patients. Clin Lab Haematol 2003;25:161-6.

  87. Kaltenbach G, Noblet-Dick M, Andres E, Barnier-Figue G, Noel E, Vogel T, et al. Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency. Ann Med Interne 2003;154:91-5.

  88. Andres E, Kaltenbach G, Noblet-Dick M, Noel E, Vinzio S, Perrin AE, et al. Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients. J Nutr Health Aging 2006;10:3-6.

  89. Andrès E, Loukili NH, Noel E, Maloisel F, Vinzio S, Kaltenbach G, et al. Oral cobalamin (daily dose of 1000 µg) therapy for the treatment of patients with pernicious anemia. An open label study of 10 patients. Curr Ther Research 2005;66:13-22.

  90. Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther 2003;25:3124-34.

  91. Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH, et al. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med 2005;165:1167-72

  92. Butler CC, Vidal-Alaball J, Cannings-John R, McCaddon A, Hood K, Papaioannou A, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Fam Pract 2006;23:279-85.

  93. Slot WB, Merkus FW, Van Deventer SJ, Tytgat GN. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology 1997;113:430-3.

  94. Abyad A. Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging 2002;6:254-60.

  95. Andres E, Kaltenbach G. Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging 2003;7:309-10. (author reply 11).

  96. Gröber U, Kisters K, Schmidt J. Neuroenhancement with vitamin B12-underestimated neurological significance. Nutrients. 2013 Dec 12;5(12):5031-45.

  97. Malouf M, Grimley EJ, Areosa SA. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database Syst Rev. 2003;(4):CD004514.

  98. Malek N, Green J. Cognition enhancers for the treatment of dementia. Scott Med J 2014 Nov 27. [Epub ahead of print]

  99. Remington R et al. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease. J Alzheimers Dis. 2015 Jan 7. [Epub ahead of print]

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