Berberine is een belangrijke bioactieve stof in verschillende populaire medicinale planten (waaronder Berberis aristata, Berberis vulgaris en Coptis chinensis), die al duizenden jaren verspreid over de wereld worden gebruikt, zoals in India, China, Japan, Iran, Rusland, Amerika en Europa.(1-4) De primaire toepassing van berberinerijke kruiden is het bestrijden van (gastro-intestinale) infecties en diarree. Andere (traditionele) toepassingen zijn bijvoorbeeld dyspepsie, lever- en galblaasproblemen, koorts, wonden, diabetes mellitus, kanker en astma.(4-6) Berberine kan worden geïsoleerd uit medicinale planten en als voedingssupplement worden ingezet, meestal in de vorm van berberine(hydro)chloride of berberinesulfaat. In Aziatische landen (met name China) wordt berberine sinds de jaren vijftig van de vorige eeuw op grote schaal gebruikt vanwege de effectiviteit bij maagdarminfecties en diarree en het goede veiligheidsprofiel.(2,7,8) Ook is berberine al voorgeschreven bij diabetes type 2, hypertensie, hartfalen, ontstekingen en leverziekten.(9) Berberine is in deze landen goed verkrijgbaar en (veel) goedkoper dan reguliere medicijnen.
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