VGBC2024 | The Dance between our Microbiome and our DNA

Ann Lannoye


Personalised healthcare is based on the premise that we are all unique – through deeper understanding of an individuals’ genotype, together with other functional biomarkers we can transform the healthcare environment to achieve:

  • Prediction and prevention of disease
  • More precise diagnoses
  • Personalised and targeted interventions and
  • A more participatory role for patients.1

This workshop will highlight the importance of this emerging field through use of practical, gut-health examples in clinical care, and how, through adopting this approach we can take a step closer to realising the above.
We will explore the interaction between HLA genes, risk for gluten intolerance and sensitivity, and  functional gut biomarkers, antigliadin antibodies and zonulin2–4. Evidence around these associations and impact on health will be highlighted, and practical guidelines to improve outcomes will be presented. Other gene-phenotype-environment interactions that will be presented include, the role of histamine genes and their effect on gut health5, as well as the crosstalk between gut health and detoxification pathways6.

About the speaker

Ann Lannoye is a Functional Medicine Practitioner with over 20 years of clinical experience in the field of Orthomolecular Medicine, Functional Medicine, Functional Nutrition and Functional Neurology.

Having owned and run a nursing home for severely ill elderly people in Belgium for over 25 years, Ann is now a strong advocator of preventive health care. Ann is committed to helping practitioners and their clients extend the quality of life and health through a better understanding of the underlying mechanisms of chronic conditions, and by early interventions in lifestyle and nutrition.

Over the last 20 years she has built a unique personalised medicine approach based on new knowledge and clinical experience in these fields, most recently, working in South Africa in a clinic concept that mainly uses DNA testing for their treatment strategies.
Ann is a sought after international medical adviser and educator.

References

  1. NHS England » Personalised medicine. Accessed February 27, 2024. https://www.england.nhs.uk/healthcare-science/personalisedmedicine/
  2. Infantino M, Manfredi M, Meacci F, et al. Diagnostic accuracy of anti-gliadin antibodies in Non-Celiac Gluten Sensitivity (NCGS) patients. Clinica Chimica Acta. 2015;451:135-141. doi:10.1016/j.cca.2015.09.017
  3. Lammi A, Arikoski P, Hakulinen A, et al. Development of gliadin-specific immune responses in children with HLA-associated genetic risk for celiac disease. Scandinavian Journal of Gastroenterology. 2016;51(2):168-177. doi:10.3109/00365521.2015.1067328
  4. Voisine J, Abadie V. Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. Frontiers in Immunology. 2021;12. Accessed February 27, 2024. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2...
  5. Shulpekova YO, Nechaev VM, Popova IR, et al. Food Intolerance: The Role of Histamine. Nutrients. 2021;13(9):3207. doi:10.3390/nu13093207
  6. Strand J. Distinctive Detoxification: The Case for Including the Microbiome in Detox Strategy. Integr Med (Encinitas). 2022;21(4):26-30.

VGBC2024