Het ketogeen dieet, dat sinds 1920 bekend staat als een effectieve behandeling voor therapieresistente epilepsie, krijgt momenteel veel aandacht van zowel wetenschappers als de media. Er komen steeds meer aanwijzingen dat dit dieet een breed scala aan gezondheidseffecten heeft. Door verbetering van de metabole gezondheid kan het al binnen enkele weken leiden tot een merkbaar gezondheidseffect. Voor veel mensen is dit reden om van het ketogeen dieet een leefstijl te maken met als doel gezond en vitaal te blijven.
Beste bezoeker, u heeft geen toegang.
Enkel (web)abonnees hebben toegang tot tijdschriftartikelen. Het webabonnement is nog in de maak.
U kunt zich wel alvast (gratis) registreren en tal van andere webartikelen raadplegen!
Auteur
Trefwoorden:
Verschenen in
Referenties
Zweers H, van Wegberg AMJ, Janssen MCH, et al. Ketogenic diet for mitochondrial disease: a systematic review on efficacy and safety. Orphanet J Rare Dis. 2021;16:1–15.
Fahed M, Abou Jaoudeh MG, Merhi S, et al. Evaluation of risk factors for insulin resistance: a cross sectional study among employees at a private university in Lebanon. BMC Endocr Disord. 2020;20:1–14.
Kosmas CE, Bousvarou MD, Kostara CE, et al. Insulin resistance and cardiovascular disease. J Int Med Res. 2023;51(3):03000605231164548.
Skow SL, Jha RK. A ketogenic diet is effective in improving insulin sensitivity in individuals with type 2 diabetes. Curr Diabetes Rev. 2023;19(6):119–29.
Hite AH, Berkowitz VG, Berkowitz K. Low‐carbohydrate diet review: shifting the paradigm. Nutr Clin Pract. 2011;26(3):300–8.
Paoli A, Bianco A, Moro T, et al. The effects of ketogenic diet on insulin sensitivity and weight loss, which came first: the chicken or the egg? Nutrients. 2023;15(14):3120.
Llorente-Folch I, Düssmann H, Watters O, et al. Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics. Sci Rep. 2023;13(1):19664.
Miller VJ. The effect of a ketogenic diet on mitochondria function in human skeletal muscle during adaptation to chronic exercise training and the potential involvement of metabolic dysregulation. The Ohio State University; 2019.
Koerich ACC, Borszcz FK, Thives Mello A, et al. Effects of the ketogenic diet on performance and body composition in athletes and trained adults: A systematic review and Bayesian multivariate multilevel meta-analysis and meta-regression. Crit Rev Food Sci Nutr. 2023;63(32):11399–424.
Keys A (1970). Coronary heart disease in seven countries. Circulation. 41 (4): 1–200.
Dong T, Guo M, Zhang P, et al. The effects of low-carbohydrate diets on cardiovascular risk factors: a meta-analysis. PLoS One. 2020;15(1):e0225348.
Faghihnia N, Tsimikas S, Miller ER, et al. Changes in lipoprotein (a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. J Lipid Res. 2010;51(11):3324–30.
Hyde PN, Sapper TN, Crabtree CD, et al. Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI insight. 2019;4(12).
Westman EC, Yancy Jr WS, Olsen MK, et al. Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses. Int J Cardiol. 2006;110(2):212–6.
EFSA Panel on Dietetic Products and Allergies (NDA). Scientific opinion on dietary reference values for carbohydrates and dietary fibre. EFSA J. 2010;8(3):1462.
Dehghan M, Mente A, Zhang X, et al. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet. 2017;390(10107):2050–62.
Vekic J, Zeljkovic A, Cicero AFG, et al. Atherosclerosis development and progression: the role of atherogenic small, dense LDL. Medicina (B Aires). 2022;58(2):299.
Kosmas CE, Rodriguez Polanco S, Bousvarou MD, et al. The triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio as a risk marker for metabolic syndrome and cardiovascular disease. Diagnostics. 2023;13(5):929.
Fu C, Liu D, Liu Q, et al. Revisiting an old relationship: the causal associations of the ApoB/ApoA1 ratio with cardiometabolic diseases and relative risk factors—a mendelian randomization analysis. Cardiovasc Diabetol. 2024;23(1):51.
Suarez R, Chapela S, Llobera ND, et al. Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism? Curr Nutr Rep. 2024;1–11.
Ji J, Fotros D, Sohouli MH, et al. The effect of a ketogenic diet on inflammation-related markers: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2024;nuad175.
Surh Y-J, Kundu JK, Na H-K. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008;74(13):1526–39.
Tozzi R, Cipriani F, Masi D, et al. Ketone bodies and SIRT1, synergic epigenetic regulators for metabolic health: a narrative review. Nutrients. 2022;14(15):3145.
Yin J, Han P, Tang Z, et al. Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke. J Cereb Blood Flow Metab. 2015;35(11):1783–9.
Kolb H, Kempf K, Röhling M, et al. Ketone bodies: from enemy to friend and guardian angel. BMC Med. 2021;19:1–15.
Garner S, Davies E, Barkus E, et al. Ketogenic diet has a positive association with mental and emotional well-being in the general population. Nutrition. 2024;124:112420.
Kraeuter A-K, Phillips R, Sarnyai Z. Ketogenic therapy in neurodegenerative and psychiatric disorders: From mice to men. Prog Neuro-Psychopharmacology Biol Psychiatry. 2020;101:109913.
Cheng B, Yang X, An L, et al. Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson’s disease. Brain Res. 2009;1286:25–31.
Dahlin M, Månsson J-E, Åmark P. CSF levels of dopamine and serotonin, but not norepinephrine, metabolites are influenced by the ketogenic diet in children with epilepsy. Epilepsy Res. 2012;99(1–2):132–8.
Castellano C-A, Hudon C, Croteau E, et al. Links between metabolic and structural changes in the brain of cognitively normal older adults: a 4-year longitudinal follow-up. Front Aging Neurosci. 2019;11:15.
Altayyar M, Nasser JA, Thomopoulos D, et al. The implication of physiological ketosis on the cognitive brain: A narrative review. Nutrients. 2022;14(3):513.
Xie G, Zhou Q, Qiu C-Z, et al. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy. World J Gastroenterol. 2017;23(33):6164.
Zhang Y, Zhou S, Zhou Y, et al. Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet. Epilepsy Res. 2018;145:163–8.
Falkenhain K, Roach LA, McCreary S, et al. Effect of carbohydrate-restricted dietary interventions on LDL particle size and number in adults in the context of weight loss or weight maintenance: a systematic review and meta-analysis. Am J Clin Nutr. 2021;114(4):1455–66.
De La Motte K-AL, Zinn C. The nutrient profile and cost of specialty dietary patterns: a hypothetical case study. Public Health Nutr. 2023;26(12):2995–3004.
Watanabe M, Tuccinardi D, Ernesti I, et al. Scientific evidence underlying contraindications to the ketogenic diet: An update. Obes Rev. 2020;21(10):e13053.