Biotine, een B-vitamine, is een cofactor van enzymen die HCO3- in moleculen inbouwen, een belangrijke stap in de stofwisseling van aminozuren. Sommige personen hebben een genetisch gebrek aan enzymen die biotine recycleren en hebben er een hogere behoefte aan (nutrigenetica). Een andere onderzoekslijn toont dat biotine in de celkern gebruikt wordt om de toegankelijkheid van het DNA te regelen (epigenetica). De toekomst zal nog veel meer brengen, want biotine regelt de expressie van duizenden genen via nog onduidelijke mechanismen.
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- [No authors listed] Biotin. Altern Med Rev. 2007 Mar;12(1):73-8. No abstract available.
- Chew YC, West JT et al. Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr. 2008 Dec;138(12):2316-22
- Fenech M, Baghurst P et al. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability--results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis. 2005 May;26(5):991-9
- Gravel RA, Narang MA. Molecular genetics of biotin metabolism: old vitamin, new science. J Nutr Biochem. 2005 Jul;16(7):428-31
- Hassan YI, Zempleni J. Epigenetic regulation of chromatin structure and gene function by biotin. J Nutr. 2006 Jul;136(7):1763-5
- Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr. 2002 Feb;75(2):295-9
- Mock DM. Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice. J Nutr. 2009 Jan;139(1):154-7>
- Oguma S, Ando I et al. Biotin ameliorates muscle cramps of hemodialysis patients: a prospective trial. Tohoku J Exp Med. 2012;227(3):217-23.
- Ogundele MO. Question 2. What is the incidence of biotin deficiency in preschool children with global developmental delay? Arch Dis Child. 2011 Sep;96(9):895-7
- Tabarki B, Al-Shafi S, Al-Shahwan S et al. Biotin-responsive basal ganglia disease revisited: clinical, radiologic, and genetic findings. Neurology. 2013 Jan 15;80(3):261-7
- Wolf B. Biotinidase deficiency: "if you have to have an inherited metabolic disease, this is the one to have". Genet Med. 2012 Jun;14(6):565-75
- Zempleni J, Chew YC, Hassan YI, Wijeratne SS. Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met? Nutr Rev. 2008 Aug;66 Suppl 1:S46-8.
- Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008 Nov 1;3(6):715-724
- Zempleni J, Kuroishi T. Biotin. Adv Nutr. 2012 Mar 1;3(2):213-4
- Zempleni J, Liu D, Teixeira Camara D, Cordonier EL. Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism. Nutr Rev. 2014 Jun;72(6):369-76
- Zempleni J, Teixeira DC et al. Biotin requirements for DNA damage prevention. Mutat Res. 2012 May 1;733(1-2):58-60
• [No authors listed] Biotin. Altern Med Rev. 2007 Mar;12(1):73-8. No abstract available.
• Chew YC, West JT et al. Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr. 2008 Dec;138(12):2316-22
• Fenech M, Baghurst P et al. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, beta-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability--results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis. 2005 May;26(5):991-9
• Gravel RA, Narang MA. Molecular genetics of biotin metabolism: old vitamin, new science. J Nutr Biochem. 2005 Jul;16(7):428-31
• Hassan YI, Zempleni J. Epigenetic regulation of chromatin structure and gene function by biotin. J Nutr. 2006 Jul;136(7):1763-5
• Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr. 2002 Feb;75(2):295-9
• Mock DM. Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice. J Nutr. 2009 Jan;139(1):154-7>
• Oguma S, Ando I et al. Biotin ameliorates muscle cramps of hemodialysis patients: a prospective trial. Tohoku J Exp Med. 2012;227(3):217-23.
• Ogundele MO. Question 2. What is the incidence of biotin deficiency in preschool children with global developmental delay? Arch Dis Child. 2011 Sep;96(9):895-7
• Tabarki B, Al-Shafi S, Al-Shahwan S et al. Biotin-responsive basal ganglia disease revisited: clinical, radiologic, and genetic findings. Neurology. 2013 Jan 15;80(3):261-7
• Wolf B. Biotinidase deficiency: "if you have to have an inherited metabolic disease, this is the one to have". Genet Med. 2012 Jun;14(6):565-75
• Zempleni J, Chew YC, Hassan YI, Wijeratne SS. Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met? Nutr Rev. 2008 Aug;66 Suppl 1:S46-8.
• Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008 Nov 1;3(6):715-724
• Zempleni J, Kuroishi T. Biotin. Adv Nutr. 2012 Mar 1;3(2):213-4
• Zempleni J, Liu D, Teixeira Camara D, Cordonier EL. Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism. Nutr Rev. 2014 Jun;72(6):369-76
• Zempleni J, Teixeira DC et al. Biotin requirements for DNA damage prevention. Mutat Res. 2012 May 1;733(1-2):58-60
