IJzerstapelingsziekte ofwel hemochromatose is een ziekte waarbij het lichaam te veel ijzer vasthoudt. Hemochromatose komt voor als erfelijke primaire/hereditaire hemochromatose of ontstaat secundair ten gevolge van veelvuldige bloedtransfusies of overmatige inname van ijzerbevattende supplementen. Ook beenmergziekten (myelodysplastisch syndroom) waarbij de aanmaak van bloedcellen is verstoord, thalassemie en verschillende hemoglobinopathieën kunnen leiden tot secundaire hemochromatose.
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