Waarom kan bij een te lage koperstatus het koperniveau in het serum toch nog normaal zijn? De oplossing voor deze paradox ligt in de relatie tussen koper en zink, en de manier waarop koper in het bloed behandeld wordt. Weinig enzymen hebben koper nodig, maar die enzymen vervullen belangrijke functies. De koperbehoefte is nog voorwerp van discussie.
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