Het aminozuur methionine
Essentieel met mate

Meer is niet altijd beter: dat zien we ook bij het essentiële aminozuur methionine. Essentieel wil zeggen dat het in de voeding aanwezig moet zijn. In de westerse voeding zit er alleszins meer dan genoeg en experimenteel onderzoek suggereert dat methionine-restrictie levensverlengend werkt, net zoals calorierestrictie. Maar klinisch onderzoek is nog niet ver geraakt. De stand van zaken.

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Auteur

Joost Meeusen

Trefwoorden:

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Referenties

  1. Meeusen J. Vasten en calorierestrictie. Minder eten = langer leven? AT&A. 2011; 6︎.
  2. Solon-Biet SM, McMahon AC, Ballard JWO, et al. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metab. 2020 Mar 3;31(3):654. Erratum for: Cell Metab. 2014 Mar 4;19(3):418-30.
  3. Orentreich N, Matias JR, DeFelice A, et al. 1993. Low methionine ingestion by rats extends life span. J. Nutr 123:269–74︎.
  4. Fang H, Stone KP, Wanders D, et al. The Origins, Evolution, and Future of Dietary Methionine Restriction. Annu Rev Nutr. 2022 Aug 22;42:201-226.
  5. Nys M. Fytohormese. Hoe planten ons sterker en gezonder maken. AT&A. 2015; 5︎.
  6. Olsen T, Øvrebø B, Turner C, et al. Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study. BMC Res Notes. 2021; 14(1):43.︎
  7. Olsen T, Øvrebø B, Haj-Yasein N, et al. Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. J Transl Med. 2020 Mar 11;18(1):122.
  8. Castaño-Martinez T, Schumacher F, Schumacher S, et al. Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J. 2019 Jun;33(6):7092-7102.
  9. Plaisance EP, Greenway FL, Boudreau A, et al. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metab. 2011 May;96(5):E836-40.
  10. Tarrago L, Kaya A, Kim HY, et al. The selenoprotein methionine sulfoxide reductase B1 (MSRB1). Free Radic Biol Med. 2022; 191:228-240.
  11. Oien DB, Moskovitz J. Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system. Biochim Biophys Acta Mol Basis Dis. 2019; 1865(7):1756-1762.
  12. Kosakamoto H, Obata F, Kuraishi J, et al. Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila. Nat Commun. 2023; 14(1):7832 doi:10.1038/s41467-023-43550-2︎.
  13. Thyne KM, Salmon AB. Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA). Sci Rep. 2022; 12(1):5073.︎
  14. Zhang Y, Jelleschitz J, Grune T, et al. Methionine restriction - Association with redox homeostasis and implications on aging and diseases. Redox Biol. 2022; 57:102464.
  15. Tessari P, Cecchet D, Vettore M, et al. Decreased Homocysteine Trans-Sulfuration in Hypertension With Hyperhomocysteinemia: Relationship With Insulin Resistance. J Clin Endocrinol Metab. 2018 Jan 1;103(1):56-63.
  16. Sedillo JC, Cryns VL. Targeting the methionine addiction of cancer. Am J Cancer Res. 2022 May 15;12(5):2249-2276︎.
  17. Tripathi SJ, Chakraborty S, Miller E, et al. Hydrogen sulfide signalling in neurodegenerative diseases. Br J Pharmacol. 2023 Jun 20:10.1111/bph.16170.
  18. Bełtowski J, Wójcicka G, Jamroz-Wiśniewska A. Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: Implications for the pathogenesis and treatment of diabetes mellitus. Biochem Pharmacol. 2018 Mar;149:60-76.
  19. Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimer’s disease. Biochem Biophys Res Commun. 2002 May 24;293(5):1485-8.
  20. Liu XQ, Liu XQ, Jiang P, et al. Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer’s disease and vascular dementia and the significance thereof. Zhonghua Yi Xue Za Zhi. 2008; 88(32):2246-9︎.
  21. Ji M, Xu X, Xu Q, et al. Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab. 2023; 5(9):1526-1543.
  22. Olsen T, Vinknes KJ, Barvíková K, et al. Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression. Redox Biol. 2024; 73:103192.
  23. Haulrik N, Toubro S, Dyerberg J, et al. Effect of protein and methionine intakes on plasma homocysteine concentrations: a 6-mo randomized controlled trial in overweight subjects. Am J Clin Nutr. 2002 Dec;76(6):1202-6.
  24. Hoffman RM, Erbe RW. High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine. Proc Natl Acad Sci U S A. 1976 May;73(5):1523-7.
  25. Hoffman RM. Clinical Studies of Methionine-Restricted Diets for Cancer Patients. Methods Mol Biol. 2019;1866:95-105.
  26. Abo Qoura L, Balakin KV, Hoffman RM, et al. The potential of methioninase for cancer treatment. Biochim Biophys Acta Rev Cancer. 2024 Jul;1879(4):189122.
  27. Kubota Y, Han Q, Hamada K, et al. Long-term Stable Disease in a Rectal-cancer Patient Treated by Methionine Restriction With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2022; 42(8):3857-3861.
  28. Han Q, Hoffman RM. Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase. Anticancer Res. 2021; 41(4):1921-1926.
  29. Tan Y, Zavala J Sr, Xu M, et al. Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients. Anticancer Res. 1996 Nov-Dec;16(6C):3937-42︎.
  30. Sato M, Han Q, Mori R, et al. Reduction of Tumor Biomarkers from very High to Normal and Extensive Metastatic Lesions to Undetectability in a Patient With Stage IV HER2-positive Breast Cancer Treated With Low-dose Trastuzumab Deruxtecan in Combination With Oral Recombinant Methioninase and a Low-methionine Diet. Anticancer Res. 2024 Apr;44(4):1499-1504.︎
  31. Sato M, Han Q, Mizuta K, et al. Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet. In Vivo. 2024 May-Jun;38(3):1459-1464.
  32. Kubota Y, Han Q, Hozumi C, et al. Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease. Anticancer Res. 2022 May;42(5):2567-2572.
  33. Epner DE. Can dietary methionine restriction increase the effectiveness of chemotherapy in treatment of advanced cancer? J Am Coll Nutr. 2001; 20(5 Suppl):443S-449S; discussion 473S-475S︎.
  34. Epner DE, Morrow S, Wilcox M, et al. Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction. Nutr Cancer. 2002; 42(2):158-66︎.
  35. Durando X, Farges MC, Buc E, et al. Dietary methionine restriction with FOLFOX regimen as first line therapy of metastatic colorectal cancer: a feasibility study. Oncology. 2010; 78(3-4):205-9.
  36. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila). 2022 Feb;15(2):101-110.
  37. Bassett JK, Severi G, Hodge AM, et al. Dietary intake of B vitamins and methionine and prostate cancer incidence and mortality. Cancer Causes Control. 2012; 23(6):855-63.
  38. Bassett JK, Hodge AM, English DR, et al. Dietary intake of B vitamins and methionine and risk of lung cancer. Eur J Clin Nutr. 2012; 66(2):182-7.
  39. Gong Z, Holly EA, Bracci PM. Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control study. Cancer Causes Control. 2009; 20(8):1317-25.
  40. Zhang CX, Ho SC, Chen YM, et al. Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status. Br J Nutr. 2011 Sep;106(6):936-43.
  41. Bassett JK, Severi G, Hodge AM, et al. Dietary intake of B vitamins and methionine and colorectal cancer risk. Nutr Cancer. 2013; 65(5):659-67.
  42. Zhou ZY, Wan XY, Cao JW. Dietary methionine intake and risk of incident colorectal cancer: a meta-analysis of 8 prospective studies involving 431,029 participants. PLoS One. 2013; 8(12):e83588.
  43. Dong Z, Gao X, Chinchilli VM, et al. Association of dietary sulfur amino acid intake with mortality from diabetes and other causes. Eur J Nutr. 2022 Feb;61(1):289-298.
  44. Schmidt JA, Rinaldi S, Scalbert A, et al. Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur J Clin Nutr. 2016 Mar;70(3):306-12.
  45. McCarty MF, Barroso-Aranda J, Contreras F. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses. 2009 Feb;72(2):125-8.
  46. Norman K, Klaus S. Veganism, aging and longevity: new insight into old concepts. Curr Opin Clin Nutr Metab Care. 2020 Mar;23(2):145-150.
  47. Osterholt T, Gloistein C, Todorova P, et al. Preoperative Short-Term Restriction of Sulfur-Containing Amino Acid Intake for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Double-Blind, Translational Trial. J Am Heart Assoc. 2022; 11(17):e025229.
  48. Plummer JD, Horowitz MC, Johnson JE. Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction. Aging Biol. 2024; 2.
  49. Johnson AA, Cuellar TL. Glycine and aging: Evidence and mechanisms. Ageing Res Rev. 2023; 87:101922.
  50. Cruz M, Maldonado-Bernal C, Mondragón-Gonzalez R, et al. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. J Endocrinol Invest. 2008 Aug;31(8):694-9.
  51. Austad SN, Smith JR, Hoffman JM. Amino acid restriction, aging, and longevity: an update. Front Aging. 2024 May 2;5:1393216.
  52. Lee BC, Kaya A, Gladyshev VN. Methionine restriction and life-span control. Ann N Y Acad Sci. 2016 Jan;1363:116-24.

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