De gezondheidsaspecten van vitamine K lijken veel verder te gaan dan die van de bloedstolling. Uit beschikbaar klinisch onderzoek blijkt dat een hoge vitamine K-status een beschermende rol speelt bij inflammatie- en mineralisatieprocessen, die geassocieerd zijn met de ontwikkeling en progressie van verouderingsziekten. Is vitamine K het super-micronutriënt van de toekomst dat ons gaat beschermen tegen het zogenoemde ‘inflamm-aging’?
Beste bezoeker, u heeft geen toegang.
Enkel (web)abonnees hebben toegang tot tijdschriftartikelen. Het webabonnement is nog in de maak.
U kunt zich wel alvast (gratis) registreren en tal van andere webartikelen raadplegen!
Auteur
Trefwoorden:
Verschenen in
Referenties
Harshman, S.G. The role of vitamin K in chronic aging diseases: inflammation, cardiovascular disease, and osteoarthritis. Current nutrition reports, 2016, 5.2: 90-98.
XV, Fan, et al. Research progress on the anticancer effects of vitamin K2. Oncology letters, 2018, 15.6: 8926-8934.
Fujii, S., et al. Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives—Investigations on identified and putative vitamin K2 metabolites. Bioorganic & medicinal chemistry, 2015, 23.10: 2344-2352.
Ohsaki, Y., et al. Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. The Journal of nutritional biochemistry, 2010, 21.11: 1120-1126.
Shea, M. K., et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. American journal of epidemiology, 2007, 167.3: 313-320.
Li, J. Vitamin K prevents oxidative cell death by inhibiting activation of 12‐lipoxygenase in developing oligodendrocytes. Journal of neuroscience research, 2009, 87.9: 1997-2005.
Cranenburg, E. C. et al. Vitamin K intake and status are low in hemodialysis patients. Kidney international, 2012, 82.5: 605-610.
Mott, A., et al. Effect of vitamin K on bone mineral density and fractures in adults: An updated systematic review and meta-analysis of randomised controlled trials. Osteoporosis International, 2019, 1-17.
Rafael, M. S., et al. Insights into the association of G la‐rich protein and osteoarthritis, novel splice variants and γ‐carboxylation status. Molecular nutrition & food research, 2014, 58.8: 1636-1646.
Cavaco, S., et al. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cellular and molecular life sciences, 2016, 73.5: 1051-1065.
Ebina, K., et al. Vitamin K2 administration is associated with decreased disease activity in patients with rheumatoid arthritis. Modern rheumatology, 2013, 23.5: 1001-1007.
Abdel-Rahman, M. S. et al. Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study. European journal of pharmacology, 2015, 761: 273-278.
Schurgeres, L. J., et al. Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood, 2006, 109.8: 3279-3283.
Beulens, J. W, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis, 2009, 203.2: 489-493.
Geleijnse, J. M., et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. The Journal of nutrition, 2004, 134.11: 3100-3105.
Krueger, T., et al. Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): a rationale and study protocol. Nephrology Dialysis Transplantation, 2013, 29.9: 1633-1638.
Vossen, L., et al. Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC Trial). Nutrients, 2015, 7.11: 8905-8915.
Lindholt, J.S, et al. Effects of menaquinone-7 supplementation in patients with aortic valve calcification: study protocol for a randomised controlled trial. BMJ open, 2018, 8.8: e022019.
Franceschi, C., et al. Inflamm‐aging: an evolutionary perspective on immunosenescence. Annals of the new York Academy of Sciences, 2000, 908.1: 244-254.
Mukai, K., et al. Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution. Journal of Biological Chemistry, 1992, 267.31: 22277-22281.
Shea, M., et al. Vitamin K status and mobility limitation and disability in older adults: The Health, Aging, and Body Composition Study. The Journals of Gerontology: Series A, 2019.
Viegas, C.S., et al. Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases. PLoS One, 2017, 12.5: e0177829.
van Ballegooijen, A.J.et al. Vitamin K status and physical decline in older adults-The Longitudinal Aging Study Amsterdam. Maturitas 2018, 113, 73–79.
Shea, M. , et al. The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Osteoarthritis and cartilage, 2015, 23.3: 370-378.
Wang, J. et al. Biological processes and biomarkers related to frailty in older adults: a state-of-the-science literature review. Biological research for nursing, 2019, 21.1: 80-106.
Simes, D. C., et al. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. International journal of molecular sciences, 2019, 20.17: 4150.
